Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units. A multiparametric optimization of the relaxin B-chain led to the i...

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Detalles Bibliográficos
Autores principales: Illiano, Stephane, Poirier, Bruno, Minoletti, Claire, Pasquier, Olivier, Riva, Laurence, Chenede, Xavier, Menguy, Isabelle, Guillotel, Michel, Prigent, Philippe, Le Claire, Stéphane, Gillot, Florence, Thill, Gilbert, Lo Presti, François, Corbier, Alain, Le Bail, Jean-Christophe, Grailhe, Patrick, Monteagudo, Edith, Ingenito, Raffaele, Bianchi, Elisabetta, Philippo, Christophe, Duclos, Olivier, Mallart, Sergio, Bathgate, Ross, Janiak, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705314/
https://www.ncbi.nlm.nih.gov/pubmed/36443381
http://dx.doi.org/10.1038/s41598-022-24716-2

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