Tumor growth inhibition and immune system activation following treatment with thorium-227 conjugates and PD-1 check-point inhibition in the MC-38 murine model

Targeted thorium-227 conjugates comprise the combination of a monoclonal antibody with specificity for a tumor cell antigen and a 3,2-HOPO chelator enabling complexation of thorium-227 (Th-227). The radiolabeled conjugate functions as an effective delivery system of alpha-particle radiation to the s...

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Detalles Bibliográficos
Autores principales: Berg-Larsen, Axel, Mobergslien, Anne, Moen, Ingrid, Petros, Gebregziabher, Kristian, Alexander, Gunvaldsen, Kristine Sponheim, Cruciani, Véronique, Wickstroem, Katrine, Bjerke, Roger Malerbakken, Karlsson, Jenny, Cuthbertson, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705341/
https://www.ncbi.nlm.nih.gov/pubmed/36457578
http://dx.doi.org/10.3389/fmed.2022.1033303

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