Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG

Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. Here we observe an enrichment of transcription factor genes including HNF1B within PCa risk-associated regions. While focused...

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Detalles Bibliográficos
Autores principales: Giannareas, Nikolaos, Zhang, Qin, Yang, Xiayun, Na, Rong, Tian, Yijun, Yang, Yuehong, Ruan, Xiaohao, Huang, Da, Yang, Xiaoqun, Wang, Chaofu, Zhang, Peng, Manninen, Aki, Wang, Liang, Wei, Gong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705428/
https://www.ncbi.nlm.nih.gov/pubmed/36443337
http://dx.doi.org/10.1038/s41467-022-34994-z

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