Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

Peptides, polymers of amino acids, comprise a vital and expanding therapeutic approach. Their rapid degradation by proteases, however, represents a major limitation to their therapeutic utility and chemical modifications to native peptides have been employed to mitigate this weakness. Herein, we des...

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Detalles Bibliográficos
Autores principales: Altiti, Ahmad, He, Mingzhu, VanPatten, Sonya, Cheng, Kai Fan, Ahmed, Umair, Chiu, Pui Yan, Mughrabi, Ibrahim T., Jabari, Bayan Al, Burch, Ronald M., Manogue, Kirk R., Tracey, Kevin J., Diamond, Betty, Metz, Christine N., Yang, Huan, Hudson, LaQueta K., Zanos, Stavros, Son, Myoungsun, Sherry, Barbara, Coleman, Thomas R., Al-Abed, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705435/
https://www.ncbi.nlm.nih.gov/pubmed/36443291
http://dx.doi.org/10.1038/s41467-022-34712-9

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