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Asymptomatic bacteriospermia and infertility—what is the connection?
OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705509/ https://www.ncbi.nlm.nih.gov/pubmed/35471630 http://dx.doi.org/10.1007/s15010-022-01828-5 |
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author | Volz, Yannic Ebner, Benedikt Pfitzinger, Paulo Berg, Elena Lellig, Ekaterina Marcon, Julian Trottmann, Matthias Becker, Armin Stief, Christian G. Magistro, Giuseppe |
author_facet | Volz, Yannic Ebner, Benedikt Pfitzinger, Paulo Berg, Elena Lellig, Ekaterina Marcon, Julian Trottmann, Matthias Becker, Armin Stief, Christian G. Magistro, Giuseppe |
author_sort | Volz, Yannic |
collection | PubMed |
description | OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regression models to evaluate the strain-specific association with semen parameters. RESULTS: Asymptomatic bacteriospermia was diagnosed in 3.2% of patients. The microbiological semen analysis revealed a poly-microbial result in 60%. The most common bacterial species were coagulase-negative Staphylococci species (71.4%), Streptococcus viridans (50.0%) and Enterococcus faecalis (26.2%). Sexually transmitted pathogens were identified in 11.9% of semen samples. The detection of Streptococcus viridians or Haemophilus parainfluenzae correlated with impaired sperm morphology (p < 0.05). The presence of coagulase-negative Staphylococci species or Enterococcus faecalis was associated with pathological low counts of live spermatozoa (p < 0.05). In multivariate analysis only Enterococcus faecalis showed a significant impact on sperm concentration (OR 4.48; 95% CI 1.06–22.10; p = 0.041). CONCLUSIONS: Asymptomatic bacteriospermia has always been a subject of great controversy. There is still an ongoing debate whether to treat or not to treat. Here, we demonstrate that asymptomatic bacteriospermia is clearly associated with impaired semen quality. Our findings speak in favour of strain-specific interactions with semen parameters. Especially Enterococcus faecalis seriously affects sperm concentration. |
format | Online Article Text |
id | pubmed-9705509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-97055092022-11-30 Asymptomatic bacteriospermia and infertility—what is the connection? Volz, Yannic Ebner, Benedikt Pfitzinger, Paulo Berg, Elena Lellig, Ekaterina Marcon, Julian Trottmann, Matthias Becker, Armin Stief, Christian G. Magistro, Giuseppe Infection Original Paper OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regression models to evaluate the strain-specific association with semen parameters. RESULTS: Asymptomatic bacteriospermia was diagnosed in 3.2% of patients. The microbiological semen analysis revealed a poly-microbial result in 60%. The most common bacterial species were coagulase-negative Staphylococci species (71.4%), Streptococcus viridans (50.0%) and Enterococcus faecalis (26.2%). Sexually transmitted pathogens were identified in 11.9% of semen samples. The detection of Streptococcus viridians or Haemophilus parainfluenzae correlated with impaired sperm morphology (p < 0.05). The presence of coagulase-negative Staphylococci species or Enterococcus faecalis was associated with pathological low counts of live spermatozoa (p < 0.05). In multivariate analysis only Enterococcus faecalis showed a significant impact on sperm concentration (OR 4.48; 95% CI 1.06–22.10; p = 0.041). CONCLUSIONS: Asymptomatic bacteriospermia has always been a subject of great controversy. There is still an ongoing debate whether to treat or not to treat. Here, we demonstrate that asymptomatic bacteriospermia is clearly associated with impaired semen quality. Our findings speak in favour of strain-specific interactions with semen parameters. Especially Enterococcus faecalis seriously affects sperm concentration. Springer Berlin Heidelberg 2022-04-26 2022 /pmc/articles/PMC9705509/ /pubmed/35471630 http://dx.doi.org/10.1007/s15010-022-01828-5 Text en © The Author(s) 2022, , corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Volz, Yannic Ebner, Benedikt Pfitzinger, Paulo Berg, Elena Lellig, Ekaterina Marcon, Julian Trottmann, Matthias Becker, Armin Stief, Christian G. Magistro, Giuseppe Asymptomatic bacteriospermia and infertility—what is the connection? |
title | Asymptomatic bacteriospermia and infertility—what is the connection? |
title_full | Asymptomatic bacteriospermia and infertility—what is the connection? |
title_fullStr | Asymptomatic bacteriospermia and infertility—what is the connection? |
title_full_unstemmed | Asymptomatic bacteriospermia and infertility—what is the connection? |
title_short | Asymptomatic bacteriospermia and infertility—what is the connection? |
title_sort | asymptomatic bacteriospermia and infertility—what is the connection? |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705509/ https://www.ncbi.nlm.nih.gov/pubmed/35471630 http://dx.doi.org/10.1007/s15010-022-01828-5 |
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