Cargando…

Asymptomatic bacteriospermia and infertility—what is the connection?

OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regr...

Descripción completa

Detalles Bibliográficos
Autores principales: Volz, Yannic, Ebner, Benedikt, Pfitzinger, Paulo, Berg, Elena, Lellig, Ekaterina, Marcon, Julian, Trottmann, Matthias, Becker, Armin, Stief, Christian G., Magistro, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705509/
https://www.ncbi.nlm.nih.gov/pubmed/35471630
http://dx.doi.org/10.1007/s15010-022-01828-5
_version_ 1784840299334336512
author Volz, Yannic
Ebner, Benedikt
Pfitzinger, Paulo
Berg, Elena
Lellig, Ekaterina
Marcon, Julian
Trottmann, Matthias
Becker, Armin
Stief, Christian G.
Magistro, Giuseppe
author_facet Volz, Yannic
Ebner, Benedikt
Pfitzinger, Paulo
Berg, Elena
Lellig, Ekaterina
Marcon, Julian
Trottmann, Matthias
Becker, Armin
Stief, Christian G.
Magistro, Giuseppe
author_sort Volz, Yannic
collection PubMed
description OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regression models to evaluate the strain-specific association with semen parameters. RESULTS: Asymptomatic bacteriospermia was diagnosed in 3.2% of patients. The microbiological semen analysis revealed a poly-microbial result in 60%. The most common bacterial species were coagulase-negative Staphylococci species (71.4%), Streptococcus viridans (50.0%) and Enterococcus faecalis (26.2%). Sexually transmitted pathogens were identified in 11.9% of semen samples. The detection of Streptococcus viridians or Haemophilus parainfluenzae correlated with impaired sperm morphology (p < 0.05). The presence of coagulase-negative Staphylococci species or Enterococcus faecalis was associated with pathological low counts of live spermatozoa (p < 0.05). In multivariate analysis only Enterococcus faecalis showed a significant impact on sperm concentration (OR 4.48; 95% CI 1.06–22.10; p = 0.041). CONCLUSIONS: Asymptomatic bacteriospermia has always been a subject of great controversy. There is still an ongoing debate whether to treat or not to treat. Here, we demonstrate that asymptomatic bacteriospermia is clearly associated with impaired semen quality. Our findings speak in favour of strain-specific interactions with semen parameters. Especially Enterococcus faecalis seriously affects sperm concentration.
format Online
Article
Text
id pubmed-9705509
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-97055092022-11-30 Asymptomatic bacteriospermia and infertility—what is the connection? Volz, Yannic Ebner, Benedikt Pfitzinger, Paulo Berg, Elena Lellig, Ekaterina Marcon, Julian Trottmann, Matthias Becker, Armin Stief, Christian G. Magistro, Giuseppe Infection Original Paper OBJECTIVE: To determine the impact of asymptomatic bacteriospermia on semen quality in subfertile men. METHODS: We conducted a retrospective, single-centre cohort study in 1300 subfertile men. In those diagnosed with asymptomatic bacteriospermia we performed univariate and multivariate logistic regression models to evaluate the strain-specific association with semen parameters. RESULTS: Asymptomatic bacteriospermia was diagnosed in 3.2% of patients. The microbiological semen analysis revealed a poly-microbial result in 60%. The most common bacterial species were coagulase-negative Staphylococci species (71.4%), Streptococcus viridans (50.0%) and Enterococcus faecalis (26.2%). Sexually transmitted pathogens were identified in 11.9% of semen samples. The detection of Streptococcus viridians or Haemophilus parainfluenzae correlated with impaired sperm morphology (p < 0.05). The presence of coagulase-negative Staphylococci species or Enterococcus faecalis was associated with pathological low counts of live spermatozoa (p < 0.05). In multivariate analysis only Enterococcus faecalis showed a significant impact on sperm concentration (OR 4.48; 95% CI 1.06–22.10; p = 0.041). CONCLUSIONS: Asymptomatic bacteriospermia has always been a subject of great controversy. There is still an ongoing debate whether to treat or not to treat. Here, we demonstrate that asymptomatic bacteriospermia is clearly associated with impaired semen quality. Our findings speak in favour of strain-specific interactions with semen parameters. Especially Enterococcus faecalis seriously affects sperm concentration. Springer Berlin Heidelberg 2022-04-26 2022 /pmc/articles/PMC9705509/ /pubmed/35471630 http://dx.doi.org/10.1007/s15010-022-01828-5 Text en © The Author(s) 2022, , corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Volz, Yannic
Ebner, Benedikt
Pfitzinger, Paulo
Berg, Elena
Lellig, Ekaterina
Marcon, Julian
Trottmann, Matthias
Becker, Armin
Stief, Christian G.
Magistro, Giuseppe
Asymptomatic bacteriospermia and infertility—what is the connection?
title Asymptomatic bacteriospermia and infertility—what is the connection?
title_full Asymptomatic bacteriospermia and infertility—what is the connection?
title_fullStr Asymptomatic bacteriospermia and infertility—what is the connection?
title_full_unstemmed Asymptomatic bacteriospermia and infertility—what is the connection?
title_short Asymptomatic bacteriospermia and infertility—what is the connection?
title_sort asymptomatic bacteriospermia and infertility—what is the connection?
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705509/
https://www.ncbi.nlm.nih.gov/pubmed/35471630
http://dx.doi.org/10.1007/s15010-022-01828-5
work_keys_str_mv AT volzyannic asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT ebnerbenedikt asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT pfitzingerpaulo asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT bergelena asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT lelligekaterina asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT marconjulian asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT trottmannmatthias asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT beckerarmin asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT stiefchristiang asymptomaticbacteriospermiaandinfertilitywhatistheconnection
AT magistrogiuseppe asymptomaticbacteriospermiaandinfertilitywhatistheconnection