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Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc

Systemic sclerosis (SSc)-related digital ischaemia is a major cause of morbidity, resulting from a combination of microvascular and digital artery disease. Photoacoustic imaging offers a newly available, non-invasive method of imaging digital artery structure and oxygenation. The aim of this study w...

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Autores principales: Wilkinson, Sarah, Cummings, James, Zafar, Sakif, Kozar, Martin, Manning, Joanne, Dinsdale, Graham, Berks, Michael, Taylor, Christopher, Dickinson, Mark, Herrick, Ariane L., Murray, Andrea K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705533/
https://www.ncbi.nlm.nih.gov/pubmed/36443311
http://dx.doi.org/10.1038/s41598-022-23826-1
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author Wilkinson, Sarah
Cummings, James
Zafar, Sakif
Kozar, Martin
Manning, Joanne
Dinsdale, Graham
Berks, Michael
Taylor, Christopher
Dickinson, Mark
Herrick, Ariane L.
Murray, Andrea K.
author_facet Wilkinson, Sarah
Cummings, James
Zafar, Sakif
Kozar, Martin
Manning, Joanne
Dinsdale, Graham
Berks, Michael
Taylor, Christopher
Dickinson, Mark
Herrick, Ariane L.
Murray, Andrea K.
author_sort Wilkinson, Sarah
collection PubMed
description Systemic sclerosis (SSc)-related digital ischaemia is a major cause of morbidity, resulting from a combination of microvascular and digital artery disease. Photoacoustic imaging offers a newly available, non-invasive method of imaging digital artery structure and oxygenation. The aim of this study was to establish whether photoacoustic imaging could detect and measure vasculopathy in digital arteries, including the level of oxygenation, in patients with SSc and healthy controls. 22 patients with SSc and 32 healthy controls (HC) underwent photoacoustic imaging of the fingers. Vascular volume and oxygenation were assessed across eight fingers at the middle phalanx. In addition, oxygenation change during finger occlusion was measured at the non-dominant ring finger and the vascular network was imaged along the length of one finger for qualitative assessment. There was no statistically significant difference in vascular volume between patients with SSc and HC (mean of eight fingers; SSc, median 118.6 IQR [95.0–130.5] vs. HC 115.6 [97.8–158.9]) mm(3). However, baseline oxygenation (mean 8 fingers) was lower in SSc vs. HC (0.373 [0.361–0.381] vs. 0.381 [0.373–0.385] arbitrary sO2 units respectively; p = 0.03). Hyperaemic oxygenation response following occlusion release was significantly lower in SSc compared to HC (0.379 [0.376–0.381] vs. 0.382 [0.377–0.385]; p = 0.03). Whilst vascular volume was similar between groups, digital artery oxygenation was decreased in patients with SSc as compared to HC, indicative of functional deficit. Photoacoustic imaging offers an exciting new method to image the vascular network in patients with SSc and the possibility to capture oxygenation as a functional measure.
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spelling pubmed-97055332022-11-30 Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc Wilkinson, Sarah Cummings, James Zafar, Sakif Kozar, Martin Manning, Joanne Dinsdale, Graham Berks, Michael Taylor, Christopher Dickinson, Mark Herrick, Ariane L. Murray, Andrea K. Sci Rep Article Systemic sclerosis (SSc)-related digital ischaemia is a major cause of morbidity, resulting from a combination of microvascular and digital artery disease. Photoacoustic imaging offers a newly available, non-invasive method of imaging digital artery structure and oxygenation. The aim of this study was to establish whether photoacoustic imaging could detect and measure vasculopathy in digital arteries, including the level of oxygenation, in patients with SSc and healthy controls. 22 patients with SSc and 32 healthy controls (HC) underwent photoacoustic imaging of the fingers. Vascular volume and oxygenation were assessed across eight fingers at the middle phalanx. In addition, oxygenation change during finger occlusion was measured at the non-dominant ring finger and the vascular network was imaged along the length of one finger for qualitative assessment. There was no statistically significant difference in vascular volume between patients with SSc and HC (mean of eight fingers; SSc, median 118.6 IQR [95.0–130.5] vs. HC 115.6 [97.8–158.9]) mm(3). However, baseline oxygenation (mean 8 fingers) was lower in SSc vs. HC (0.373 [0.361–0.381] vs. 0.381 [0.373–0.385] arbitrary sO2 units respectively; p = 0.03). Hyperaemic oxygenation response following occlusion release was significantly lower in SSc compared to HC (0.379 [0.376–0.381] vs. 0.382 [0.377–0.385]; p = 0.03). Whilst vascular volume was similar between groups, digital artery oxygenation was decreased in patients with SSc as compared to HC, indicative of functional deficit. Photoacoustic imaging offers an exciting new method to image the vascular network in patients with SSc and the possibility to capture oxygenation as a functional measure. Nature Publishing Group UK 2022-11-28 /pmc/articles/PMC9705533/ /pubmed/36443311 http://dx.doi.org/10.1038/s41598-022-23826-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wilkinson, Sarah
Cummings, James
Zafar, Sakif
Kozar, Martin
Manning, Joanne
Dinsdale, Graham
Berks, Michael
Taylor, Christopher
Dickinson, Mark
Herrick, Ariane L.
Murray, Andrea K.
Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title_full Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title_fullStr Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title_full_unstemmed Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title_short Photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with SSc
title_sort photoacoustic imaging is a novel tool to measure finger artery structure and oxygenation in patients with ssc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705533/
https://www.ncbi.nlm.nih.gov/pubmed/36443311
http://dx.doi.org/10.1038/s41598-022-23826-1
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