Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but the long presymptomatic phase and poor correlation between Aβ deposition and clinical symptoms remain puzzling. To elucidate the dependency of downstream pathologies on Aβ, we analyzed the trajectories of c...

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Detalles Bibliográficos
Autores principales: Rother, Christine, Uhlmann, Ruth E., Müller, Stephan A., Schelle, Juliane, Skodras, Angelos, Obermüller, Ulrike, Häsler, Lisa M., Lambert, Marius, Baumann, Frank, Xu, Ying, Bergmann, Carina, Salvadori, Giulia, Loos, Maarten, Brzak, Irena, Shimshek, Derya, Neumann, Ulf, Walker, Lary C., Schultz, Stephanie A., Chhatwal, Jasmeer P., Kaeser, Stephan A., Lichtenthaler, Stefan F., Staufenbiel, Matthias, Jucker, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705543/
https://www.ncbi.nlm.nih.gov/pubmed/36443293
http://dx.doi.org/10.1038/s41467-022-34538-5

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