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Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units
INTRODUCTION: COVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705573/ https://www.ncbi.nlm.nih.gov/pubmed/36458163 http://dx.doi.org/10.3389/fnut.2022.975937 |
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author | Hashemian, Seyed MohammadReza Mortaz, Esmaeil Shafigh, Navid Ziaie, Shadi Jamaati, Hamidreza Hasheminik, Morteza Jamalinik, Mehdi Erfani, Raziyeh Khoundabi, Batoul Dezfuli, Neda K. Varahram, Mohammad Ahmadi, Shahrzad Fahimi, Mahdi Adcock, Ian M. |
author_facet | Hashemian, Seyed MohammadReza Mortaz, Esmaeil Shafigh, Navid Ziaie, Shadi Jamaati, Hamidreza Hasheminik, Morteza Jamalinik, Mehdi Erfani, Raziyeh Khoundabi, Batoul Dezfuli, Neda K. Varahram, Mohammad Ahmadi, Shahrzad Fahimi, Mahdi Adcock, Ian M. |
author_sort | Hashemian, Seyed MohammadReza |
collection | PubMed |
description | INTRODUCTION: COVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting. MATERIALS AND METHODS: A pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release. RESULTS: All the measured parameters decreased significantly with BPS treatment. In the control group, most parameters significantly improved apart from AST and PCT. In addition, the suppression of serum TNF levels in the BPS group was greater than that seen in the control group (P ≤ 0.05). Moreover, the length of ICU stay was significantly lower in the BPS group compared with the control group (P ≤ 0.05). CONCLUSION: Our study shows that addition of BPS to the standard treatment regime of COVID-19 patients in ICU improved outcomes and reduced the length of ICU treatment. Natural products could be considered as new approaches for reducting the harmful consequences of COVID-19. |
format | Online Article Text |
id | pubmed-9705573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97055732022-11-30 Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units Hashemian, Seyed MohammadReza Mortaz, Esmaeil Shafigh, Navid Ziaie, Shadi Jamaati, Hamidreza Hasheminik, Morteza Jamalinik, Mehdi Erfani, Raziyeh Khoundabi, Batoul Dezfuli, Neda K. Varahram, Mohammad Ahmadi, Shahrzad Fahimi, Mahdi Adcock, Ian M. Front Nutr Nutrition INTRODUCTION: COVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting. MATERIALS AND METHODS: A pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release. RESULTS: All the measured parameters decreased significantly with BPS treatment. In the control group, most parameters significantly improved apart from AST and PCT. In addition, the suppression of serum TNF levels in the BPS group was greater than that seen in the control group (P ≤ 0.05). Moreover, the length of ICU stay was significantly lower in the BPS group compared with the control group (P ≤ 0.05). CONCLUSION: Our study shows that addition of BPS to the standard treatment regime of COVID-19 patients in ICU improved outcomes and reduced the length of ICU treatment. Natural products could be considered as new approaches for reducting the harmful consequences of COVID-19. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9705573/ /pubmed/36458163 http://dx.doi.org/10.3389/fnut.2022.975937 Text en Copyright © 2022 Hashemian, Mortaz, Shafigh, Ziaie, Jamaati, Hasheminik, Jamalinik, Erfani, Khoundabi, Dezfuli, Varahram, Ahmadi, Fahimi and Adcock. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Hashemian, Seyed MohammadReza Mortaz, Esmaeil Shafigh, Navid Ziaie, Shadi Jamaati, Hamidreza Hasheminik, Morteza Jamalinik, Mehdi Erfani, Raziyeh Khoundabi, Batoul Dezfuli, Neda K. Varahram, Mohammad Ahmadi, Shahrzad Fahimi, Mahdi Adcock, Ian M. Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title_full | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title_fullStr | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title_full_unstemmed | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title_short | Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units |
title_sort | effectiveness of borage plus syrup on covid-19 patients in intensive care units |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705573/ https://www.ncbi.nlm.nih.gov/pubmed/36458163 http://dx.doi.org/10.3389/fnut.2022.975937 |
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