Cargando…
Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study
Various studies have described the roles of myeloid-derived suppressor cells (MDSCs) in pathological conditions, but relatively few have described them under normal physiological conditions. Accumulation of MDSCs is important creating an anti-inflammation environment, which is essential for fertiliz...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705596/ https://www.ncbi.nlm.nih.gov/pubmed/36457573 http://dx.doi.org/10.3389/fmed.2022.940554 |
_version_ | 1784840320259719168 |
---|---|
author | Xu, Qiying Liu, Huifang Qile, Muge Wuren, Tana |
author_facet | Xu, Qiying Liu, Huifang Qile, Muge Wuren, Tana |
author_sort | Xu, Qiying |
collection | PubMed |
description | Various studies have described the roles of myeloid-derived suppressor cells (MDSCs) in pathological conditions, but relatively few have described them under normal physiological conditions. Accumulation of MDSCs is important creating an anti-inflammation environment, which is essential for fertilized egg implantation. This study was designed to record the dynamic changes in MDSC-like cells composition during the menstrual period (MP) and ovulation period (OP) in healthy volunteers over the course of a single menstrual cycle to explore the association between MDSCs and the menstrual cycle under normal physiological conditions. The ratio of MDSC-like cells was higher in MP samples, whereas the activity of Arg-1 was higher during the OP window. There was a negative correlation between the ratio of MDSC-like cells and the percentage of lymphocytes and a positive correlation between MDSC-like cells and prostaglandin E2 (PGE2). Furthermore, regular changes in the ratio and function of MDSC-like cells in the peripheral blood were observed during menstruation, all of which corresponded to the cycle stage. During menstruation, MDSCs may promote endometrial repair, whereas they promote pregnancy during the OP. These findings may help to better understand the pathophysiology of pregnancy-related complications and lay a foundation for improving perinatal outcomes. |
format | Online Article Text |
id | pubmed-9705596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97055962022-11-30 Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study Xu, Qiying Liu, Huifang Qile, Muge Wuren, Tana Front Med (Lausanne) Medicine Various studies have described the roles of myeloid-derived suppressor cells (MDSCs) in pathological conditions, but relatively few have described them under normal physiological conditions. Accumulation of MDSCs is important creating an anti-inflammation environment, which is essential for fertilized egg implantation. This study was designed to record the dynamic changes in MDSC-like cells composition during the menstrual period (MP) and ovulation period (OP) in healthy volunteers over the course of a single menstrual cycle to explore the association between MDSCs and the menstrual cycle under normal physiological conditions. The ratio of MDSC-like cells was higher in MP samples, whereas the activity of Arg-1 was higher during the OP window. There was a negative correlation between the ratio of MDSC-like cells and the percentage of lymphocytes and a positive correlation between MDSC-like cells and prostaglandin E2 (PGE2). Furthermore, regular changes in the ratio and function of MDSC-like cells in the peripheral blood were observed during menstruation, all of which corresponded to the cycle stage. During menstruation, MDSCs may promote endometrial repair, whereas they promote pregnancy during the OP. These findings may help to better understand the pathophysiology of pregnancy-related complications and lay a foundation for improving perinatal outcomes. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9705596/ /pubmed/36457573 http://dx.doi.org/10.3389/fmed.2022.940554 Text en Copyright © 2022 Xu, Liu, Qile and Wuren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Xu, Qiying Liu, Huifang Qile, Muge Wuren, Tana Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title | Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title_full | Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title_fullStr | Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title_full_unstemmed | Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title_short | Dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: A pilot study |
title_sort | dynamic changes in myeloid-derived suppressor cells during the menstrual cycle: a pilot study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705596/ https://www.ncbi.nlm.nih.gov/pubmed/36457573 http://dx.doi.org/10.3389/fmed.2022.940554 |
work_keys_str_mv | AT xuqiying dynamicchangesinmyeloidderivedsuppressorcellsduringthemenstrualcycleapilotstudy AT liuhuifang dynamicchangesinmyeloidderivedsuppressorcellsduringthemenstrualcycleapilotstudy AT qilemuge dynamicchangesinmyeloidderivedsuppressorcellsduringthemenstrualcycleapilotstudy AT wurentana dynamicchangesinmyeloidderivedsuppressorcellsduringthemenstrualcycleapilotstudy |