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Mental health progress requires causal diagnostic nosology and scalable causal discovery

Nine hundred and seventy million individuals across the globe are estimated to carry the burden of a mental disorder. Limited progress has been achieved in alleviating this burden over decades of effort, compared to progress achieved for many other medical disorders. Progress on outcome improvement...

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Autores principales: Saxe, Glenn N., Bickman, Leonard, Ma, Sisi, Aliferis, Constantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705733/
https://www.ncbi.nlm.nih.gov/pubmed/36458123
http://dx.doi.org/10.3389/fpsyt.2022.898789
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author Saxe, Glenn N.
Bickman, Leonard
Ma, Sisi
Aliferis, Constantin
author_facet Saxe, Glenn N.
Bickman, Leonard
Ma, Sisi
Aliferis, Constantin
author_sort Saxe, Glenn N.
collection PubMed
description Nine hundred and seventy million individuals across the globe are estimated to carry the burden of a mental disorder. Limited progress has been achieved in alleviating this burden over decades of effort, compared to progress achieved for many other medical disorders. Progress on outcome improvement for all medical disorders, including mental disorders, requires research capable of discovering causality at sufficient scale and speed, and a diagnostic nosology capable of encoding the causal knowledge that is discovered. Accordingly, the field’s guiding paradigm limits progress by maintaining: (a) a diagnostic nosology (DSM-5) with a profound lack of causality; (b) a misalignment between mental health etiologic research and nosology; (c) an over-reliance on clinical trials beyond their capabilities; and (d) a limited adoption of newer methods capable of discovering the complex etiology of mental disorders. We detail feasible directions forward, to achieve greater levels of progress on improving outcomes for mental disorders, by: (a) the discovery of knowledge on the complex etiology of mental disorders with application of Causal Data Science methods; and (b) the encoding of the etiological knowledge that is discovered within a causal diagnostic system for mental disorders.
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spelling pubmed-97057332022-11-30 Mental health progress requires causal diagnostic nosology and scalable causal discovery Saxe, Glenn N. Bickman, Leonard Ma, Sisi Aliferis, Constantin Front Psychiatry Psychiatry Nine hundred and seventy million individuals across the globe are estimated to carry the burden of a mental disorder. Limited progress has been achieved in alleviating this burden over decades of effort, compared to progress achieved for many other medical disorders. Progress on outcome improvement for all medical disorders, including mental disorders, requires research capable of discovering causality at sufficient scale and speed, and a diagnostic nosology capable of encoding the causal knowledge that is discovered. Accordingly, the field’s guiding paradigm limits progress by maintaining: (a) a diagnostic nosology (DSM-5) with a profound lack of causality; (b) a misalignment between mental health etiologic research and nosology; (c) an over-reliance on clinical trials beyond their capabilities; and (d) a limited adoption of newer methods capable of discovering the complex etiology of mental disorders. We detail feasible directions forward, to achieve greater levels of progress on improving outcomes for mental disorders, by: (a) the discovery of knowledge on the complex etiology of mental disorders with application of Causal Data Science methods; and (b) the encoding of the etiological knowledge that is discovered within a causal diagnostic system for mental disorders. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9705733/ /pubmed/36458123 http://dx.doi.org/10.3389/fpsyt.2022.898789 Text en Copyright © 2022 Saxe, Bickman, Ma and Aliferis. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Saxe, Glenn N.
Bickman, Leonard
Ma, Sisi
Aliferis, Constantin
Mental health progress requires causal diagnostic nosology and scalable causal discovery
title Mental health progress requires causal diagnostic nosology and scalable causal discovery
title_full Mental health progress requires causal diagnostic nosology and scalable causal discovery
title_fullStr Mental health progress requires causal diagnostic nosology and scalable causal discovery
title_full_unstemmed Mental health progress requires causal diagnostic nosology and scalable causal discovery
title_short Mental health progress requires causal diagnostic nosology and scalable causal discovery
title_sort mental health progress requires causal diagnostic nosology and scalable causal discovery
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705733/
https://www.ncbi.nlm.nih.gov/pubmed/36458123
http://dx.doi.org/10.3389/fpsyt.2022.898789
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