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Washed microbiota transplantation improves patients with metabolic syndrome in South China

BACKGROUND: Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients is unclear, especially in southern Chinese populations. This study aimed to investigate the effect of washed microbiota t...

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Autores principales: Wu, Lei, Lu, Xin-Jian, Lin, De-Jiang, Chen, Wen-Jia, Xue, Xing-Ying, Liu, Tao, Xu, Jia-Ting, Xie, Ya-Ting, Li, Man-Qing, Lin, Wen-Ying, Zhang, Qing, Wu, Qing-Ping, He, Xing-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705737/
https://www.ncbi.nlm.nih.gov/pubmed/36457852
http://dx.doi.org/10.3389/fcimb.2022.1044957
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author Wu, Lei
Lu, Xin-Jian
Lin, De-Jiang
Chen, Wen-Jia
Xue, Xing-Ying
Liu, Tao
Xu, Jia-Ting
Xie, Ya-Ting
Li, Man-Qing
Lin, Wen-Ying
Zhang, Qing
Wu, Qing-Ping
He, Xing-Xiang
author_facet Wu, Lei
Lu, Xin-Jian
Lin, De-Jiang
Chen, Wen-Jia
Xue, Xing-Ying
Liu, Tao
Xu, Jia-Ting
Xie, Ya-Ting
Li, Man-Qing
Lin, Wen-Ying
Zhang, Qing
Wu, Qing-Ping
He, Xing-Xiang
author_sort Wu, Lei
collection PubMed
description BACKGROUND: Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients is unclear, especially in southern Chinese populations. This study aimed to investigate the effect of washed microbiota transplantation (WMT) in MS patients in southern China. METHODS: The clinical data of patients with different indications receiving 1-3 courses of WMT were retrospectively collected. The changes of BMI, blood glucose, blood lipids, blood pressure and other indicators before and after WMT were compared, such as fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c)), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein (non-HDL-c), systolic blood pressure (SBP), diastolic blood pressure (DBP), etc. At the same time, comprehensive efficacy evaluation and atherosclerotic cardiovascular disease (ASCVD) grade assessment were performed on MS patients. Finally, 16S rRNA gene amplicon sequencing was performed on fecal samples of MS patients before and after transplantation. RESULTS: A total of 237 patients were included, including 42 in the MS group and 195 in the non-MS group. For MS patients, WMT significantly improved the comprehensive efficacy of MS in short term 40.48% (p<0.001), medium term 36.00% (p=0.003), and long term 46.15% (p=0.020). Short-term significantly reduced FBG (p=0.023), TG (p=0.030), SBP (p=0.026) and BMI (p=0.031), and increased HDL-c (p=0.036). The medium term had a significant reduction in FBG (p=0.048), TC (p=0.022), LDL-c (p=0.043), non-HDL-c (p=0.024) and BMI (p=0.048). WMT had a significant short term (p=0.029) and medium term (p=0.011) ASCVD downgrading effect in the high-risk group of MS patients. WMT improved gut microbiota in MS patients. CONCLUSION: WMT had a significant improvement effect on MS patients and a significant downgrade effect on ASCVD risk in the high-risk group of patients with MS. WMT could restore gut microbiota homeostasis in MS patients. Therefore, the regulation of gut microbiota by WMT may provide a new clinical approach for the treatment of MS.
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spelling pubmed-97057372022-11-30 Washed microbiota transplantation improves patients with metabolic syndrome in South China Wu, Lei Lu, Xin-Jian Lin, De-Jiang Chen, Wen-Jia Xue, Xing-Ying Liu, Tao Xu, Jia-Ting Xie, Ya-Ting Li, Man-Qing Lin, Wen-Ying Zhang, Qing Wu, Qing-Ping He, Xing-Xiang Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients is unclear, especially in southern Chinese populations. This study aimed to investigate the effect of washed microbiota transplantation (WMT) in MS patients in southern China. METHODS: The clinical data of patients with different indications receiving 1-3 courses of WMT were retrospectively collected. The changes of BMI, blood glucose, blood lipids, blood pressure and other indicators before and after WMT were compared, such as fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c)), high-density lipoprotein cholesterol (HDL-c), non-high-density lipoprotein (non-HDL-c), systolic blood pressure (SBP), diastolic blood pressure (DBP), etc. At the same time, comprehensive efficacy evaluation and atherosclerotic cardiovascular disease (ASCVD) grade assessment were performed on MS patients. Finally, 16S rRNA gene amplicon sequencing was performed on fecal samples of MS patients before and after transplantation. RESULTS: A total of 237 patients were included, including 42 in the MS group and 195 in the non-MS group. For MS patients, WMT significantly improved the comprehensive efficacy of MS in short term 40.48% (p<0.001), medium term 36.00% (p=0.003), and long term 46.15% (p=0.020). Short-term significantly reduced FBG (p=0.023), TG (p=0.030), SBP (p=0.026) and BMI (p=0.031), and increased HDL-c (p=0.036). The medium term had a significant reduction in FBG (p=0.048), TC (p=0.022), LDL-c (p=0.043), non-HDL-c (p=0.024) and BMI (p=0.048). WMT had a significant short term (p=0.029) and medium term (p=0.011) ASCVD downgrading effect in the high-risk group of MS patients. WMT improved gut microbiota in MS patients. CONCLUSION: WMT had a significant improvement effect on MS patients and a significant downgrade effect on ASCVD risk in the high-risk group of patients with MS. WMT could restore gut microbiota homeostasis in MS patients. Therefore, the regulation of gut microbiota by WMT may provide a new clinical approach for the treatment of MS. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9705737/ /pubmed/36457852 http://dx.doi.org/10.3389/fcimb.2022.1044957 Text en Copyright © 2022 Wu, Lu, Lin, Chen, Xue, Liu, Xu, Xie, Li, Lin, Zhang, Wu and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Wu, Lei
Lu, Xin-Jian
Lin, De-Jiang
Chen, Wen-Jia
Xue, Xing-Ying
Liu, Tao
Xu, Jia-Ting
Xie, Ya-Ting
Li, Man-Qing
Lin, Wen-Ying
Zhang, Qing
Wu, Qing-Ping
He, Xing-Xiang
Washed microbiota transplantation improves patients with metabolic syndrome in South China
title Washed microbiota transplantation improves patients with metabolic syndrome in South China
title_full Washed microbiota transplantation improves patients with metabolic syndrome in South China
title_fullStr Washed microbiota transplantation improves patients with metabolic syndrome in South China
title_full_unstemmed Washed microbiota transplantation improves patients with metabolic syndrome in South China
title_short Washed microbiota transplantation improves patients with metabolic syndrome in South China
title_sort washed microbiota transplantation improves patients with metabolic syndrome in south china
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705737/
https://www.ncbi.nlm.nih.gov/pubmed/36457852
http://dx.doi.org/10.3389/fcimb.2022.1044957
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