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Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study
BACKGROUND: Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them. METHODS: Information on educational le...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705800/ https://www.ncbi.nlm.nih.gov/pubmed/36217863 http://dx.doi.org/10.1111/1753-0407.13325 |
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author | Zhu, Yuanyue Hu, Chunyan Lin, Lin Wang, Shuangyuan Lin, Hong Huo, Yanan Wan, Qin Qin, Yingfen Hu, Ruying Shi, Lixin Su, Qing Yu, Xuefeng Yan, Li Qin, Guijun Tang, Xulei Chen, Gang Xu, Min Xu, Yu Wang, Tiange Zhao, Zhiyun Gao, Zhengnan Wang, Guixia Shen, Feixia Luo, Zuojie Chen, Li Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Chen, Lulu Zeng, Tianshu Zhao, Jiajun Mu, Yiming Wang, Weiqing Ning, Guang Bi, Yufang Chen, Yuhong Lu, Jieli |
author_facet | Zhu, Yuanyue Hu, Chunyan Lin, Lin Wang, Shuangyuan Lin, Hong Huo, Yanan Wan, Qin Qin, Yingfen Hu, Ruying Shi, Lixin Su, Qing Yu, Xuefeng Yan, Li Qin, Guijun Tang, Xulei Chen, Gang Xu, Min Xu, Yu Wang, Tiange Zhao, Zhiyun Gao, Zhengnan Wang, Guixia Shen, Feixia Luo, Zuojie Chen, Li Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Chen, Lulu Zeng, Tianshu Zhao, Jiajun Mu, Yiming Wang, Weiqing Ning, Guang Bi, Yufang Chen, Yuhong Lu, Jieli |
author_sort | Zhu, Yuanyue |
collection | PubMed |
description | BACKGROUND: Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them. METHODS: Information on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self‐report and biochemical measurements. A structural equation model was constructed to quantify the mediation effect of each mediator. RESULTS: Compared with their least educated counterparts, men with college education had a higher risk of diabetes (odds ratio [OR] 1.19; 95% confidence interval [CI], 1.12–1.27), while college‐educated women were less likely to have diabetes (OR 0.77; 95% CI, 0.73–0.82). Obesity was the strongest mediator in both genders (proportion of mediation: 11.6% in men and 23.9% in women), and its association with education was positive in men (β[SE] 0.0387 [0.0037]) and negative in women (β[SE] −0.0824 [0.0030]). Taken together, all behavioral factors explained 12.4% of the excess risk of diabetes in men and 33.3% in women. CONCLUSIONS: In a general Chinese population, the association between education level and diabetes was positive in men but negative in women. Obesity was the major mediator underlying the education disparities of diabetes risk, with a stronger mediation effect among women. |
format | Online Article Text |
id | pubmed-9705800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-97058002022-11-29 Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study Zhu, Yuanyue Hu, Chunyan Lin, Lin Wang, Shuangyuan Lin, Hong Huo, Yanan Wan, Qin Qin, Yingfen Hu, Ruying Shi, Lixin Su, Qing Yu, Xuefeng Yan, Li Qin, Guijun Tang, Xulei Chen, Gang Xu, Min Xu, Yu Wang, Tiange Zhao, Zhiyun Gao, Zhengnan Wang, Guixia Shen, Feixia Luo, Zuojie Chen, Li Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Chen, Lulu Zeng, Tianshu Zhao, Jiajun Mu, Yiming Wang, Weiqing Ning, Guang Bi, Yufang Chen, Yuhong Lu, Jieli J Diabetes Original Articles BACKGROUND: Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them. METHODS: Information on educational level and lifestyle factors was collected through questionnaires. Diabetes was diagnosed from self‐report and biochemical measurements. A structural equation model was constructed to quantify the mediation effect of each mediator. RESULTS: Compared with their least educated counterparts, men with college education had a higher risk of diabetes (odds ratio [OR] 1.19; 95% confidence interval [CI], 1.12–1.27), while college‐educated women were less likely to have diabetes (OR 0.77; 95% CI, 0.73–0.82). Obesity was the strongest mediator in both genders (proportion of mediation: 11.6% in men and 23.9% in women), and its association with education was positive in men (β[SE] 0.0387 [0.0037]) and negative in women (β[SE] −0.0824 [0.0030]). Taken together, all behavioral factors explained 12.4% of the excess risk of diabetes in men and 33.3% in women. CONCLUSIONS: In a general Chinese population, the association between education level and diabetes was positive in men but negative in women. Obesity was the major mediator underlying the education disparities of diabetes risk, with a stronger mediation effect among women. Wiley Publishing Asia Pty Ltd 2022-10-11 /pmc/articles/PMC9705800/ /pubmed/36217863 http://dx.doi.org/10.1111/1753-0407.13325 Text en © 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Zhu, Yuanyue Hu, Chunyan Lin, Lin Wang, Shuangyuan Lin, Hong Huo, Yanan Wan, Qin Qin, Yingfen Hu, Ruying Shi, Lixin Su, Qing Yu, Xuefeng Yan, Li Qin, Guijun Tang, Xulei Chen, Gang Xu, Min Xu, Yu Wang, Tiange Zhao, Zhiyun Gao, Zhengnan Wang, Guixia Shen, Feixia Luo, Zuojie Chen, Li Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Chen, Lulu Zeng, Tianshu Zhao, Jiajun Mu, Yiming Wang, Weiqing Ning, Guang Bi, Yufang Chen, Yuhong Lu, Jieli Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title | Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title_full | Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title_fullStr | Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title_full_unstemmed | Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title_short | Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study |
title_sort | obesity mediates the opposite association of education and diabetes in chinese men and women: results from the reaction study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705800/ https://www.ncbi.nlm.nih.gov/pubmed/36217863 http://dx.doi.org/10.1111/1753-0407.13325 |
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