Cargando…

Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia

In the present study, we investigated the inhibitory effect of heat-killed Enterococcus faecalis (E. faecalis) and live E. faecalis on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutan...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Young-Jin, Fan, Meiqi, Tang, Yujiao, Iwasa, Masahiro, Han, Kwon-Il, Lee, Hongchan, Hwang, Ji-Young, Lee, Bokyung, Kim, Eun-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705861/
https://www.ncbi.nlm.nih.gov/pubmed/34226410
http://dx.doi.org/10.4014/jmb.2102.02032
_version_ 1784840373946810368
author Choi, Young-Jin
Fan, Meiqi
Tang, Yujiao
Iwasa, Masahiro
Han, Kwon-Il
Lee, Hongchan
Hwang, Ji-Young
Lee, Bokyung
Kim, Eun-Kyung
author_facet Choi, Young-Jin
Fan, Meiqi
Tang, Yujiao
Iwasa, Masahiro
Han, Kwon-Il
Lee, Hongchan
Hwang, Ji-Young
Lee, Bokyung
Kim, Eun-Kyung
author_sort Choi, Young-Jin
collection PubMed
description In the present study, we investigated the inhibitory effect of heat-killed Enterococcus faecalis (E. faecalis) and live E. faecalis on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutaneous injections daily for four weeks after castration. The rats were divided into five groups: Con, corn oil-injected (s.c.) + DW administration; BPH, TP (5 mg/kg, s.c.) + DW administration; BPH+K_EF, TP (5 mg/kg, s.c.) + heat-killed E. faecalis (7.5 × 10(12) CFU/g, 2.21 mg/kg) administration; BPH+L_EF, TP (5 mg/kg, s.c.) + live E. faecalis (1 × 10(11) CFU/g, 166 mg/kg) administration; BPH+Fi, TP (5 mg/kg, s.c.) + finasteride (1 mg/kg) administration. In both of BPH+K_EF and BPH+L_EF groups, the prostate weight decreased and histological changes due to TP treatment recovered to the level of the Con group. Both of these groups also showed regulation of androgen-signaling factors, growth factors, and apoptosis-related factors in prostate tissue. E. faecalis exhibited an inhibitory effect on benign prostatic hyperplasia, and even heat-killed E. faecalis showed similar efficacy on the live cells in the BPH rat model. As the first investigation into the effect of heat-killed and live E. faecalis on BPH, our study suggests that heat-killed E. faecalis might be a food additive candidate for use in various foods, regardless of heat processing.
format Online
Article
Text
id pubmed-9705861
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Korean Society for Microbiology and Biotechnology
record_format MEDLINE/PubMed
spelling pubmed-97058612022-12-13 Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia Choi, Young-Jin Fan, Meiqi Tang, Yujiao Iwasa, Masahiro Han, Kwon-Il Lee, Hongchan Hwang, Ji-Young Lee, Bokyung Kim, Eun-Kyung J Microbiol Biotechnol Research article In the present study, we investigated the inhibitory effect of heat-killed Enterococcus faecalis (E. faecalis) and live E. faecalis on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutaneous injections daily for four weeks after castration. The rats were divided into five groups: Con, corn oil-injected (s.c.) + DW administration; BPH, TP (5 mg/kg, s.c.) + DW administration; BPH+K_EF, TP (5 mg/kg, s.c.) + heat-killed E. faecalis (7.5 × 10(12) CFU/g, 2.21 mg/kg) administration; BPH+L_EF, TP (5 mg/kg, s.c.) + live E. faecalis (1 × 10(11) CFU/g, 166 mg/kg) administration; BPH+Fi, TP (5 mg/kg, s.c.) + finasteride (1 mg/kg) administration. In both of BPH+K_EF and BPH+L_EF groups, the prostate weight decreased and histological changes due to TP treatment recovered to the level of the Con group. Both of these groups also showed regulation of androgen-signaling factors, growth factors, and apoptosis-related factors in prostate tissue. E. faecalis exhibited an inhibitory effect on benign prostatic hyperplasia, and even heat-killed E. faecalis showed similar efficacy on the live cells in the BPH rat model. As the first investigation into the effect of heat-killed and live E. faecalis on BPH, our study suggests that heat-killed E. faecalis might be a food additive candidate for use in various foods, regardless of heat processing. The Korean Society for Microbiology and Biotechnology 2021-08-28 2021-06-29 /pmc/articles/PMC9705861/ /pubmed/34226410 http://dx.doi.org/10.4014/jmb.2102.02032 Text en Copyright © 2021 by The Korean Society for Microbiology and Biotechnology https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research article
Choi, Young-Jin
Fan, Meiqi
Tang, Yujiao
Iwasa, Masahiro
Han, Kwon-Il
Lee, Hongchan
Hwang, Ji-Young
Lee, Bokyung
Kim, Eun-Kyung
Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title_full Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title_fullStr Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title_full_unstemmed Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title_short Heat-Killed and Live Enterococcus faecalis Attenuates Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia
title_sort heat-killed and live enterococcus faecalis attenuates enlarged prostate in an animal model of benign prostatic hyperplasia
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705861/
https://www.ncbi.nlm.nih.gov/pubmed/34226410
http://dx.doi.org/10.4014/jmb.2102.02032
work_keys_str_mv AT choiyoungjin heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT fanmeiqi heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT tangyujiao heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT iwasamasahiro heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT hankwonil heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT leehongchan heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT hwangjiyoung heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT leebokyung heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia
AT kimeunkyung heatkilledandliveenterococcusfaecalisattenuatesenlargedprostateinananimalmodelofbenignprostatichyperplasia