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Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production

Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this p...

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Autores principales: Ahmed, Aqsa, Ahmad, Abdullah, Li, Renhan, AL-Ansi, Waleed, Fatima, Momal, Mushtaq, Bilal Sajid, Basharat, Samra, Li, Ye, Bai, Zhonghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705886/
https://www.ncbi.nlm.nih.gov/pubmed/34584039
http://dx.doi.org/10.4014/jmb.2107.07045
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author Ahmed, Aqsa
Ahmad, Abdullah
Li, Renhan
AL-Ansi, Waleed
Fatima, Momal
Mushtaq, Bilal Sajid
Basharat, Samra
Li, Ye
Bai, Zhonghu
author_facet Ahmed, Aqsa
Ahmad, Abdullah
Li, Renhan
AL-Ansi, Waleed
Fatima, Momal
Mushtaq, Bilal Sajid
Basharat, Samra
Li, Ye
Bai, Zhonghu
author_sort Ahmed, Aqsa
collection PubMed
description Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum, (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii, Corynebacterium glutamicum, and Yarrowia lipolytica, (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications.
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spelling pubmed-97058862022-12-13 Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production Ahmed, Aqsa Ahmad, Abdullah Li, Renhan AL-Ansi, Waleed Fatima, Momal Mushtaq, Bilal Sajid Basharat, Samra Li, Ye Bai, Zhonghu J Microbiol Biotechnol Review Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum, (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii, Corynebacterium glutamicum, and Yarrowia lipolytica, (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications. The Korean Society for Microbiology and Biotechnology 2021-11-28 2021-09-28 /pmc/articles/PMC9705886/ /pubmed/34584039 http://dx.doi.org/10.4014/jmb.2107.07045 Text en Copyright © 2021 by the authors. Licensee KMB. https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ahmed, Aqsa
Ahmad, Abdullah
Li, Renhan
AL-Ansi, Waleed
Fatima, Momal
Mushtaq, Bilal Sajid
Basharat, Samra
Li, Ye
Bai, Zhonghu
Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title_full Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title_fullStr Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title_full_unstemmed Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title_short Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production
title_sort recent advances in synthetic, industrial and biological applications of violacein and its heterologous production
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705886/
https://www.ncbi.nlm.nih.gov/pubmed/34584039
http://dx.doi.org/10.4014/jmb.2107.07045
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