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Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation

Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration...

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Autores principales: Park, Sung-Soo, Lim, Seul Ki, Lee, Jieun, Park, Hyo Kyeong, Kwon, Min-Sung, Yun, Misun, Kim, Namhee, Oh, Young Joon, Choi, Hak-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705947/
https://www.ncbi.nlm.nih.gov/pubmed/34528915
http://dx.doi.org/10.4014/jmb.2107.07024
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author Park, Sung-Soo
Lim, Seul Ki
Lee, Jieun
Park, Hyo Kyeong
Kwon, Min-Sung
Yun, Misun
Kim, Namhee
Oh, Young Joon
Choi, Hak-Jong
author_facet Park, Sung-Soo
Lim, Seul Ki
Lee, Jieun
Park, Hyo Kyeong
Kwon, Min-Sung
Yun, Misun
Kim, Namhee
Oh, Young Joon
Choi, Hak-Jong
author_sort Park, Sung-Soo
collection PubMed
description Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.
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spelling pubmed-97059472022-12-13 Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation Park, Sung-Soo Lim, Seul Ki Lee, Jieun Park, Hyo Kyeong Kwon, Min-Sung Yun, Misun Kim, Namhee Oh, Young Joon Choi, Hak-Jong J Microbiol Biotechnol Research article Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity. The Korean Society for Microbiology and Biotechnology 2021-11-28 2021-09-15 /pmc/articles/PMC9705947/ /pubmed/34528915 http://dx.doi.org/10.4014/jmb.2107.07024 Text en Copyright © 2021 by the authors. Licensee KMB. https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research article
Park, Sung-Soo
Lim, Seul Ki
Lee, Jieun
Park, Hyo Kyeong
Kwon, Min-Sung
Yun, Misun
Kim, Namhee
Oh, Young Joon
Choi, Hak-Jong
Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title_full Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title_fullStr Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title_full_unstemmed Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title_short Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation
title_sort latilactobacillus sakei wikim31 decelerates weight gain in high-fat diet-induced obese mice by modulating lipid metabolism and suppressing inflammation
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705947/
https://www.ncbi.nlm.nih.gov/pubmed/34528915
http://dx.doi.org/10.4014/jmb.2107.07024
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