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Neuroprotective Effect of Epalrestat on Hydrogen Peroxide-Induced Neurodegeneration in SH-SY5Y Cellular Model

Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that E...

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Detalles Bibliográficos
Autores principales:	Lingappa, Sivakumar, Shivakumar, Muthugounder Subramanian, Manivasagam, Thamilarasan, Somasundaram, Somasundaram Thirugnanasambandan, Seedevi, Palaniappan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Microbiology and Biotechnology 2021
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705952/ https://www.ncbi.nlm.nih.gov/pubmed/33820886 http://dx.doi.org/10.4014/jmb.2101.01002

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