Ferroptosis in osteosarcoma: A promising future

The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-depend...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiang, Du, Shaowen, Wang, Shengdong, Ye, Kaishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705963/
https://www.ncbi.nlm.nih.gov/pubmed/36457488
http://dx.doi.org/10.3389/fonc.2022.1031779
_version_ 1784840401521213440
author Liu, Xiang
Du, Shaowen
Wang, Shengdong
Ye, Kaishan
author_facet Liu, Xiang
Du, Shaowen
Wang, Shengdong
Ye, Kaishan
author_sort Liu, Xiang
collection PubMed
description The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-dependent lipid peroxidation. Current studies have shown that ferroptosis is closely related to OS and could reduce chemotherapy resistance to a certain extent, which has great therapeutic potential. In this paper, we review the regulatory mechanism of ferroptosis and its research progress in OS, hoping to provide new help for the clinical treatment of OS.
format Online
Article
Text
id pubmed-9705963
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97059632022-11-30 Ferroptosis in osteosarcoma: A promising future Liu, Xiang Du, Shaowen Wang, Shengdong Ye, Kaishan Front Oncol Oncology The incidence of osteosarcoma (OS) is increasing year by year, and the prognosis of patients with advanced OS is extremely poor due to the tendency of recurrence and chemotherapy resistance after surgery. Ferroptosis is a novel form of programmed cell death (PCD) that kills cells through iron-dependent lipid peroxidation. Current studies have shown that ferroptosis is closely related to OS and could reduce chemotherapy resistance to a certain extent, which has great therapeutic potential. In this paper, we review the regulatory mechanism of ferroptosis and its research progress in OS, hoping to provide new help for the clinical treatment of OS. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9705963/ /pubmed/36457488 http://dx.doi.org/10.3389/fonc.2022.1031779 Text en Copyright © 2022 Liu, Du, Wang and Ye https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Xiang
Du, Shaowen
Wang, Shengdong
Ye, Kaishan
Ferroptosis in osteosarcoma: A promising future
title Ferroptosis in osteosarcoma: A promising future
title_full Ferroptosis in osteosarcoma: A promising future
title_fullStr Ferroptosis in osteosarcoma: A promising future
title_full_unstemmed Ferroptosis in osteosarcoma: A promising future
title_short Ferroptosis in osteosarcoma: A promising future
title_sort ferroptosis in osteosarcoma: a promising future
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705963/
https://www.ncbi.nlm.nih.gov/pubmed/36457488
http://dx.doi.org/10.3389/fonc.2022.1031779
work_keys_str_mv AT liuxiang ferroptosisinosteosarcomaapromisingfuture
AT dushaowen ferroptosisinosteosarcomaapromisingfuture
AT wangshengdong ferroptosisinosteosarcomaapromisingfuture
AT yekaishan ferroptosisinosteosarcomaapromisingfuture

Ejemplares similares