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Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection

Two virulence factors of Helicobacter pylori, cagA and vacA, have been known to play a role in the development of severe gastric symptoms. However, they are not always associated with peptic ulcer or gastric cancer. To predict the disease outcome more accurately, it is necessary to understand the ri...

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Autores principales: Lee, Dong-Hae, Ha, Jong-Hun, Shin, Jeong-Ih, Kim, Kyu-Min, Choi, Jeong-gyu, Park, Seorin, Park, Jin-Sik, Seo, Ji-Hyeun, Park, Ji-Shook, Shin, Min-Kyoung, Baik, Seung-Chul, Lee, Woo-Kon, Youn, Hee-Shang, Cho, Myung-Je, Kang, Hyung-Lyun, Jung, Myunghwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Microbiology and Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705970/
https://www.ncbi.nlm.nih.gov/pubmed/33622995
http://dx.doi.org/10.4014/jmb.2101.01023
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author Lee, Dong-Hae
Ha, Jong-Hun
Shin, Jeong-Ih
Kim, Kyu-Min
Choi, Jeong-gyu
Park, Seorin
Park, Jin-Sik
Seo, Ji-Hyeun
Park, Ji-Shook
Shin, Min-Kyoung
Baik, Seung-Chul
Lee, Woo-Kon
Youn, Hee-Shang
Cho, Myung-Je
Kang, Hyung-Lyun
Jung, Myunghwan
author_facet Lee, Dong-Hae
Ha, Jong-Hun
Shin, Jeong-Ih
Kim, Kyu-Min
Choi, Jeong-gyu
Park, Seorin
Park, Jin-Sik
Seo, Ji-Hyeun
Park, Ji-Shook
Shin, Min-Kyoung
Baik, Seung-Chul
Lee, Woo-Kon
Youn, Hee-Shang
Cho, Myung-Je
Kang, Hyung-Lyun
Jung, Myunghwan
author_sort Lee, Dong-Hae
collection PubMed
description Two virulence factors of Helicobacter pylori, cagA and vacA, have been known to play a role in the development of severe gastric symptoms. However, they are not always associated with peptic ulcer or gastric cancer. To predict the disease outcome more accurately, it is necessary to understand the risk of severe symptoms linked to other virulence factors. Several other virulence factors of H. pylori have also been reported to be associated with disease outcomes, although there are many controversial descriptions. H. pylori isolates from Koreans may be useful in evaluating the relevance of other virulence factors to clinical symptoms of gastric diseases because the majority of Koreans are infected by toxigenic strains of H. pylori bearing cagA and vacA. In this study, a total of 116 H. pylori strains from Korean patients with chronic gastritis, peptic ulcers, and gastric cancers were genotyped. The presence of virulence factors vacAs1c, alpA, babA2, hopZ, and the extremely strong vacuolating toxin was found to contribute significantly to the development of severe gastric symptoms. The genotype combination vacAs1c/alpA/babA2 was the most predictable determinant for the development of severe symptoms, and the presence of babA2 was found to be the most critical factor. This study provides important information on the virulence factors that contribute to the development of severe gastric symptoms and will assist in predicting clinical disease outcomes due to H. pylori infection.
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spelling pubmed-97059702022-12-13 Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection Lee, Dong-Hae Ha, Jong-Hun Shin, Jeong-Ih Kim, Kyu-Min Choi, Jeong-gyu Park, Seorin Park, Jin-Sik Seo, Ji-Hyeun Park, Ji-Shook Shin, Min-Kyoung Baik, Seung-Chul Lee, Woo-Kon Youn, Hee-Shang Cho, Myung-Je Kang, Hyung-Lyun Jung, Myunghwan J Microbiol Biotechnol Research article Two virulence factors of Helicobacter pylori, cagA and vacA, have been known to play a role in the development of severe gastric symptoms. However, they are not always associated with peptic ulcer or gastric cancer. To predict the disease outcome more accurately, it is necessary to understand the risk of severe symptoms linked to other virulence factors. Several other virulence factors of H. pylori have also been reported to be associated with disease outcomes, although there are many controversial descriptions. H. pylori isolates from Koreans may be useful in evaluating the relevance of other virulence factors to clinical symptoms of gastric diseases because the majority of Koreans are infected by toxigenic strains of H. pylori bearing cagA and vacA. In this study, a total of 116 H. pylori strains from Korean patients with chronic gastritis, peptic ulcers, and gastric cancers were genotyped. The presence of virulence factors vacAs1c, alpA, babA2, hopZ, and the extremely strong vacuolating toxin was found to contribute significantly to the development of severe gastric symptoms. The genotype combination vacAs1c/alpA/babA2 was the most predictable determinant for the development of severe symptoms, and the presence of babA2 was found to be the most critical factor. This study provides important information on the virulence factors that contribute to the development of severe gastric symptoms and will assist in predicting clinical disease outcomes due to H. pylori infection. Korean Society for Microbiology and Biotechnology 2021-03-28 2021-02-08 /pmc/articles/PMC9705970/ /pubmed/33622995 http://dx.doi.org/10.4014/jmb.2101.01023 Text en Copyright © 2021 by The Korean Society for Microbiology and Biotechnology https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research article
Lee, Dong-Hae
Ha, Jong-Hun
Shin, Jeong-Ih
Kim, Kyu-Min
Choi, Jeong-gyu
Park, Seorin
Park, Jin-Sik
Seo, Ji-Hyeun
Park, Ji-Shook
Shin, Min-Kyoung
Baik, Seung-Chul
Lee, Woo-Kon
Youn, Hee-Shang
Cho, Myung-Je
Kang, Hyung-Lyun
Jung, Myunghwan
Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title_full Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title_fullStr Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title_full_unstemmed Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title_short Increased Risk of Severe Gastric Symptoms by Virulence Factors vacAs1c, alpA, babA2, and hopZ in Helicobacter pylori Infection
title_sort increased risk of severe gastric symptoms by virulence factors vacas1c, alpa, baba2, and hopz in helicobacter pylori infection
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705970/
https://www.ncbi.nlm.nih.gov/pubmed/33622995
http://dx.doi.org/10.4014/jmb.2101.01023
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