Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity

A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic ana...

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Autores principales: Jang, Jun-Pil, Kwon, Min Cheol, Nogawa, Toshihiko, Takahashi, Shunji, Osada, Hiroyuki, Ahn, Jong Seog, Ko, Sung-Kyun, Jang, Jae-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2021
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706031/
https://www.ncbi.nlm.nih.gov/pubmed/34528916
http://dx.doi.org/10.4014/jmb.2108.08015
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author Jang, Jun-Pil
Kwon, Min Cheol
Nogawa, Toshihiko
Takahashi, Shunji
Osada, Hiroyuki
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
author_facet Jang, Jun-Pil
Kwon, Min Cheol
Nogawa, Toshihiko
Takahashi, Shunji
Osada, Hiroyuki
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
author_sort Jang, Jun-Pil
collection PubMed
description A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
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spelling pubmed-97060312022-12-13 Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity Jang, Jun-Pil Kwon, Min Cheol Nogawa, Toshihiko Takahashi, Shunji Osada, Hiroyuki Ahn, Jong Seog Ko, Sung-Kyun Jang, Jae-Hyuk J Microbiol Biotechnol Research article A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells. The Korean Society for Microbiology and Biotechnology 2021-12-28 2021-09-15 /pmc/articles/PMC9706031/ /pubmed/34528916 http://dx.doi.org/10.4014/jmb.2108.08015 Text en Copyright © 2021 by the authors. Licensee KMB. https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research article
Jang, Jun-Pil
Kwon, Min Cheol
Nogawa, Toshihiko
Takahashi, Shunji
Osada, Hiroyuki
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title_full Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title_fullStr Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title_full_unstemmed Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title_short Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity
title_sort thiolactomide: a new homocysteine thiolactone derivative from streptomyces sp. with neuroprotective activity
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706031/
https://www.ncbi.nlm.nih.gov/pubmed/34528916
http://dx.doi.org/10.4014/jmb.2108.08015
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