Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis

Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we’ve conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function c...

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Detalles Bibliográficos
Autores principales: Li, Zhuo, Hou, Xiaomin, Liu, Xuehua, Ma, Linlin, Tan, Jiewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706077/
https://www.ncbi.nlm.nih.gov/pubmed/36458280
http://dx.doi.org/10.1177/15593258221141579
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author Li, Zhuo
Hou, Xiaomin
Liu, Xuehua
Ma, Linlin
Tan, Jiewen
author_facet Li, Zhuo
Hou, Xiaomin
Liu, Xuehua
Ma, Linlin
Tan, Jiewen
author_sort Li, Zhuo
collection PubMed
description Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we’ve conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.
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spelling pubmed-97060772022-11-30 Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis Li, Zhuo Hou, Xiaomin Liu, Xuehua Ma, Linlin Tan, Jiewen Dose Response Original Article Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we’ve conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group. SAGE Publications 2022-11-24 /pmc/articles/PMC9706077/ /pubmed/36458280 http://dx.doi.org/10.1177/15593258221141579 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Li, Zhuo
Hou, Xiaomin
Liu, Xuehua
Ma, Linlin
Tan, Jiewen
Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title_full Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title_fullStr Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title_full_unstemmed Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title_short Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis
title_sort hyperbaric oxygen therapy-induced molecular and pathway changes in a rat model of spinal cord injury: a proteomic analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706077/
https://www.ncbi.nlm.nih.gov/pubmed/36458280
http://dx.doi.org/10.1177/15593258221141579
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