Cargando…

Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches

This review article describes our simplified biophysical model for the response of a group of cells to ionizing radiation. The model, which is a product of 10 years of studies, acts as (a) a comprehensive stochastic approach based on the Monte Carlo simulation with a probability tree and (b) the the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fornalski, Krzysztof W., Adamowski, Łukasz, Bugała, Ernest, Jarmakiewicz, Rafał, Kirejczyk, Marek, Kopyciński, Jakub, Krasowska, Julianna, Kukulski, Piotr, Piotrowski, Łukasz, Ponikowska, Julia, Reszczyńska, Joanna, Słonecka, Iwona, Wysocki, Paweł, Dobrzyński, Ludwik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706082/
https://www.ncbi.nlm.nih.gov/pubmed/36458282
http://dx.doi.org/10.1177/15593258221138506
_version_ 1784840432020094976
author Fornalski, Krzysztof W.
Adamowski, Łukasz
Bugała, Ernest
Jarmakiewicz, Rafał
Kirejczyk, Marek
Kopyciński, Jakub
Krasowska, Julianna
Kukulski, Piotr
Piotrowski, Łukasz
Ponikowska, Julia
Reszczyńska, Joanna
Słonecka, Iwona
Wysocki, Paweł
Dobrzyński, Ludwik
author_facet Fornalski, Krzysztof W.
Adamowski, Łukasz
Bugała, Ernest
Jarmakiewicz, Rafał
Kirejczyk, Marek
Kopyciński, Jakub
Krasowska, Julianna
Kukulski, Piotr
Piotrowski, Łukasz
Ponikowska, Julia
Reszczyńska, Joanna
Słonecka, Iwona
Wysocki, Paweł
Dobrzyński, Ludwik
author_sort Fornalski, Krzysztof W.
collection PubMed
description This review article describes our simplified biophysical model for the response of a group of cells to ionizing radiation. The model, which is a product of 10 years of studies, acts as (a) a comprehensive stochastic approach based on the Monte Carlo simulation with a probability tree and (b) the thereof derived detailed deterministic models describing the selected biophysical and radiobiological phenomena in an analytical manner. Specifically, the presented model describes effects such as the risk of neoplastic transformation of cells relative to the absorbed radiation dose, the dynamics of tumor development, the priming dose effect (also called the Raper–Yonezawa effect) based on the introduced adaptive response approach, and the bystander effect. The model is also modifiable depending on users’ potential needs.
format Online
Article
Text
id pubmed-9706082
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-97060822022-11-30 Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches Fornalski, Krzysztof W. Adamowski, Łukasz Bugała, Ernest Jarmakiewicz, Rafał Kirejczyk, Marek Kopyciński, Jakub Krasowska, Julianna Kukulski, Piotr Piotrowski, Łukasz Ponikowska, Julia Reszczyńska, Joanna Słonecka, Iwona Wysocki, Paweł Dobrzyński, Ludwik Dose Response Low-dose scientific debate: data and scientific ethics - a special issue to commemorate Ludwik Dobrzynski This review article describes our simplified biophysical model for the response of a group of cells to ionizing radiation. The model, which is a product of 10 years of studies, acts as (a) a comprehensive stochastic approach based on the Monte Carlo simulation with a probability tree and (b) the thereof derived detailed deterministic models describing the selected biophysical and radiobiological phenomena in an analytical manner. Specifically, the presented model describes effects such as the risk of neoplastic transformation of cells relative to the absorbed radiation dose, the dynamics of tumor development, the priming dose effect (also called the Raper–Yonezawa effect) based on the introduced adaptive response approach, and the bystander effect. The model is also modifiable depending on users’ potential needs. SAGE Publications 2022-11-23 /pmc/articles/PMC9706082/ /pubmed/36458282 http://dx.doi.org/10.1177/15593258221138506 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Low-dose scientific debate: data and scientific ethics - a special issue to commemorate Ludwik Dobrzynski
Fornalski, Krzysztof W.
Adamowski, Łukasz
Bugała, Ernest
Jarmakiewicz, Rafał
Kirejczyk, Marek
Kopyciński, Jakub
Krasowska, Julianna
Kukulski, Piotr
Piotrowski, Łukasz
Ponikowska, Julia
Reszczyńska, Joanna
Słonecka, Iwona
Wysocki, Paweł
Dobrzyński, Ludwik
Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title_full Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title_fullStr Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title_full_unstemmed Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title_short Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches
title_sort biophysical modeling of the ionizing radiation influence on cells using the stochastic (monte carlo) and deterministic (analytical) approaches
topic Low-dose scientific debate: data and scientific ethics - a special issue to commemorate Ludwik Dobrzynski
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706082/
https://www.ncbi.nlm.nih.gov/pubmed/36458282
http://dx.doi.org/10.1177/15593258221138506
work_keys_str_mv AT fornalskikrzysztofw biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT adamowskiłukasz biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT bugałaernest biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT jarmakiewiczrafał biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT kirejczykmarek biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT kopycinskijakub biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT krasowskajulianna biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT kukulskipiotr biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT piotrowskiłukasz biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT ponikowskajulia biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT reszczynskajoanna biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT słoneckaiwona biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT wysockipaweł biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches
AT dobrzynskiludwik biophysicalmodelingoftheionizingradiationinfluenceoncellsusingthestochasticmontecarloanddeterministicanalyticalapproaches