Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons. As a consequence, ALS patients display a locomotor disorder related to muscle weakness and progressive paralysis. Pathological mechanisms that participate in ALS involve deficient unfolded pro...

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Detalles Bibliográficos
Autores principales: Lasbleiz, Christelle, Peyrel, Amandine, Tarot, Pauline, Sarniguet, Jérôme, Crouzier, Lucie, Cubedo, Nicolas, Delprat, Benjamin, Rossel, Mireille, Maurice, Tangui, Liévens, Jean-Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706169/
https://www.ncbi.nlm.nih.gov/pubmed/36442393
http://dx.doi.org/10.1016/j.redox.2022.102542

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