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The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus

OBJECTIVE: Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare. STUDY DESIGN AND SETTING: Clinical manifestations, laboratory examinations, and disease severity were compared between thre...

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Autores principales: Liu, Shelan, Zhu, An, Pan, Jinren, Ying, Lihong, Sun, Wanwan, Wu, Hanting, Zhu, Haiying, Lou, Haiyan, Wang, Lan, Qin, Shuwen, Yu, Zhao, Cai, Jian, Chen, Yin, Chen, Enfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706225/
https://www.ncbi.nlm.nih.gov/pubmed/36457331
http://dx.doi.org/10.3389/fpubh.2022.1048108
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author Liu, Shelan
Zhu, An
Pan, Jinren
Ying, Lihong
Sun, Wanwan
Wu, Hanting
Zhu, Haiying
Lou, Haiyan
Wang, Lan
Qin, Shuwen
Yu, Zhao
Cai, Jian
Chen, Yin
Chen, Enfu
author_facet Liu, Shelan
Zhu, An
Pan, Jinren
Ying, Lihong
Sun, Wanwan
Wu, Hanting
Zhu, Haiying
Lou, Haiyan
Wang, Lan
Qin, Shuwen
Yu, Zhao
Cai, Jian
Chen, Yin
Chen, Enfu
author_sort Liu, Shelan
collection PubMed
description OBJECTIVE: Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare. STUDY DESIGN AND SETTING: Clinical manifestations, laboratory examinations, and disease severity were compared between three groups: one coinfected with HAdV-Ad7 and HCoV-229E, one infected only with adenovirus (mono-adenovirus), and one infected only with HCoV-229E (mono-HCoV-229E). RESULTS: From July to August 2019, there were 24 hospitalized children: two were coinfected with HAdV-Ad7 and HCoV-229E, and 21 were infected with a single adenovirus infection. Finally, one 14-year-old boy presented with a high fever, but tested negative for HAdV-Ad7 and HCoV-229E. Additionally, three adult asymptotic cases with HCoV-229E were screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 vs. 8 years, p = 0.332). Both groups had the same incubation period (2.5 vs. 3 days, p = 0.8302), fever duration (2.5 vs. 2.9 days, p = 0.5062), and length of hospital stay (7 vs. 6.76 days, p = 0.640). No obvious differences were found in viral loads between the coinfection and mono-adenovirus groups (25.4 vs. 23.7, p = 0.570), or in the coinfection and mono-HCoV-229E groups (32.9 vs. 30.06, p = 0.067). All cases recovered and were discharged from the hospital. CONCLUSION: HAdV-Ad7 and HCoV-229E coinfection in healthy children may not increase the clinical severity or prolong the clinical course. The specific interaction mechanism between the viruses requires further study.
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spelling pubmed-97062252022-11-30 The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus Liu, Shelan Zhu, An Pan, Jinren Ying, Lihong Sun, Wanwan Wu, Hanting Zhu, Haiying Lou, Haiyan Wang, Lan Qin, Shuwen Yu, Zhao Cai, Jian Chen, Yin Chen, Enfu Front Public Health Public Health OBJECTIVE: Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare. STUDY DESIGN AND SETTING: Clinical manifestations, laboratory examinations, and disease severity were compared between three groups: one coinfected with HAdV-Ad7 and HCoV-229E, one infected only with adenovirus (mono-adenovirus), and one infected only with HCoV-229E (mono-HCoV-229E). RESULTS: From July to August 2019, there were 24 hospitalized children: two were coinfected with HAdV-Ad7 and HCoV-229E, and 21 were infected with a single adenovirus infection. Finally, one 14-year-old boy presented with a high fever, but tested negative for HAdV-Ad7 and HCoV-229E. Additionally, three adult asymptotic cases with HCoV-229E were screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 vs. 8 years, p = 0.332). Both groups had the same incubation period (2.5 vs. 3 days, p = 0.8302), fever duration (2.5 vs. 2.9 days, p = 0.5062), and length of hospital stay (7 vs. 6.76 days, p = 0.640). No obvious differences were found in viral loads between the coinfection and mono-adenovirus groups (25.4 vs. 23.7, p = 0.570), or in the coinfection and mono-HCoV-229E groups (32.9 vs. 30.06, p = 0.067). All cases recovered and were discharged from the hospital. CONCLUSION: HAdV-Ad7 and HCoV-229E coinfection in healthy children may not increase the clinical severity or prolong the clinical course. The specific interaction mechanism between the viruses requires further study. Frontiers Media S.A. 2022-11-15 /pmc/articles/PMC9706225/ /pubmed/36457331 http://dx.doi.org/10.3389/fpubh.2022.1048108 Text en Copyright © 2022 Liu, Zhu, Pan, Ying, Sun, Wu, Zhu, Lou, Wang, Qin, Yu, Cai, Chen and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Liu, Shelan
Zhu, An
Pan, Jinren
Ying, Lihong
Sun, Wanwan
Wu, Hanting
Zhu, Haiying
Lou, Haiyan
Wang, Lan
Qin, Shuwen
Yu, Zhao
Cai, Jian
Chen, Yin
Chen, Enfu
The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title_full The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title_fullStr The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title_full_unstemmed The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title_short The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
title_sort clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229e virus
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706225/
https://www.ncbi.nlm.nih.gov/pubmed/36457331
http://dx.doi.org/10.3389/fpubh.2022.1048108
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