Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case

BACKGROUND: Intranasal delivery of NEO100, a pharmaceutical-grade version of the natural monoterpene perillyl alcohol (POH), is undergoing clinical phase IIa testing as a treatment for glioblastoma (GBM). However, so far there is no evidence that intranasal delivery of NEO100 indeed results in POH r...

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Detalles Bibliográficos
Autores principales: Schönthal, Axel H., Swenson, Steve, Bonney, Phillip A., Wagle, Naveed, Simmon, Vincent F., Mathew, Anna J., Hurth, Kyle M., Chen, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association of Neurological Surgeons 2022
Materias:
Case Lesson
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706323/
https://www.ncbi.nlm.nih.gov/pubmed/36088606
http://dx.doi.org/10.3171/CASE22215

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