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Identification of a S-(2-succino)cysteine breakdown pathway that uses a novel S-(2-succino) lyase

Succination is the spontaneous reaction between the respiratory intermediate fumarate and cellular thiols that forms stable S-(2-succino)-adducts such as S-(2-succino)cysteine (2SC). 2SC is a biomarker for conditions associated with elevated fumarate levels, including diabetes, obesity, and certain...

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Detalles Bibliográficos
Autores principales: Hillmann, Katie B., Goethel, Madeline E., Erickson, Natalie A., Niehaus, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706529/
https://www.ncbi.nlm.nih.gov/pubmed/36309089
http://dx.doi.org/10.1016/j.jbc.2022.102639