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Identification of a S-(2-succino)cysteine breakdown pathway that uses a novel S-(2-succino) lyase
Succination is the spontaneous reaction between the respiratory intermediate fumarate and cellular thiols that forms stable S-(2-succino)-adducts such as S-(2-succino)cysteine (2SC). 2SC is a biomarker for conditions associated with elevated fumarate levels, including diabetes, obesity, and certain...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706529/ https://www.ncbi.nlm.nih.gov/pubmed/36309089 http://dx.doi.org/10.1016/j.jbc.2022.102639 |