A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors

[Image: see text] This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but has significant drawbacks. First,...

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Detalles Bibliográficos
Autores principales: d’Arcy, Richard, El Mohtadi, Farah, Francini, Nora, DeJulius, Carlisle R., Back, Hyunmoon, Gennari, Arianna, Geven, Mike, Lopez-Cavestany, Maria, Turhan, Zulfiye Yesim, Yu, Fang, Lee, Jong Bong, King, Michael R., Kagan, Leonid, Duvall, Craig L., Tirelli, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706570/
https://www.ncbi.nlm.nih.gov/pubmed/36367536
http://dx.doi.org/10.1021/jacs.2c09232

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