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Mechanism of Melatonin Metabolism by CYP1A1: What Determines the Bifurcation Pathways of Hydroxylation versus Deformylation?

[Image: see text] Melatonin, a widely applied cosmetic active ingredient, has a variety of uses as a skin protector through antioxidant and anti-inflammatory functions as well as giving the body UV-induced defenses and immune system support. In the body, melatonin is synthesized from a tryptophan am...

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Detalles Bibliográficos
Autores principales: Mokkawes, Thirakorn, Lim, Ze Qing, de Visser, Sam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706573/
https://www.ncbi.nlm.nih.gov/pubmed/36380557
http://dx.doi.org/10.1021/acs.jpcb.2c07200