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Targefrin: A Potent Agent Targeting the Ligand Binding Domain of EphA2
[Image: see text] Overexpression of the receptor tyrosine kinase EphA2 is invariably associated with poor prognosis and development of aggressive metastatic cancers. Guided by our recently solved X-ray structure of the complex between an agonistic peptide and EphA2-LBD, we report on a novel agent, t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706575/ https://www.ncbi.nlm.nih.gov/pubmed/36331527 http://dx.doi.org/10.1021/acs.jmedchem.2c01391 |