AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy

Rationale: Increased lipid droplet (LD) formation has been linked to tumor metastasis, stemness, and chemoresistance in various types of cancer. Here, we revealed that LD formation is critical for the adaptation to sorafenib in hepatocellular carcinoma (HCC) cells. We aim to investigate the LD funct...

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Detalles Bibliográficos
Autores principales: Wu, Changqing, Dai, Chaoliu, Li, Xinyu, Sun, Mingju, Chu, Hongwei, Xuan, Qiuhui, Yin, Yalei, Fang, Chengnan, Yang, Fan, Jiang, Zhonghao, Lv, Qing, He, Keqing, Qu, Yiying, Zhao, Baofeng, Cai, Ke, Zhang, Shuijun, Sun, Ran, Xu, Guowang, Zhang, Lihua, Sun, Siyu, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706585/
https://www.ncbi.nlm.nih.gov/pubmed/36451864
http://dx.doi.org/10.7150/thno.74974

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