Self-assembly of X-shaped antibody to combine the activity of IgG and IgA for enhanced tumor killing

Rationale: IgA can induce activation of neutrophils which are the most abundant cell type in blood, but the development of IgA as therapeutic has been confounded by its short half-life and a weak ability to recruit NK cells as effector cells. Therefore, we generated an X-shaped antibody (X-body) bas...

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Detalles Bibliográficos
Autores principales: Liang, Yuexia, Li, Xin, Peng, Fengping, Ye, Xiaohan, Wang, Wei, Cen, Tianyi, Li, Fan, Lu, Yue, Liu, Zhaoyun, Liu, Hui, Ding, Kai, Ye, Kai, Yu, Yang, Ma, Tianyu, Zhang, Sihe, Huang, Yi, Wang, Yuan, Yang, Xue, Fu, Rong, Zhang, Hongkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706586/
https://www.ncbi.nlm.nih.gov/pubmed/36451853
http://dx.doi.org/10.7150/thno.74903

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