Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants

BACKGROUND AND AIMS: It has been indicated that Melatonin receptor 1B (MTNR1B) gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reached now. Hence, the present meta-analysis was conducted to illuminate the potential association of human MTNR1B gene rs10830963 C/G polymorphism and T2DM. METHODS AND RESULTS: There were 13,752 participants from 7 studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed by using the fixed or random effects models. A significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM was found under recessive (OR: 1.148, 95% CI: 1.052–1.253, P = 0.002), homozygous (OR: 1.197, 95% CI: 1.023–1.401, P = 0.025), and additive (OR: 1.067, 95% CI: 1.017–1.120, P = 0.008) genetic models. CONCLUSIONS: MTNR1B gene rs10830963 C/G polymorphism was significantly related to T2DM in the Chinese population. The persons with G allele of the MTNRB1 gene rs10830963 C/G polymorphism might be the T2DM susceptible population.