Intracellular Quantum Sensing of Free-Radical Generation Induced by Acetaminophen (APAP) in the Cytosol, in Mitochondria and the Nucleus of Macrophages

[Image: see text] Acetaminophen overdoses cause cell injury in the liver. It is widely accepted that liver toxicity is initiated by the reactive N-acetyl-para-aminophenol (APAP) metabolite N-acetyl-p-benzoquinone imine (NAPQI), which first depletes glutathione and then irreversibly binds to mitochon...

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Autores principales: Sharmin, Rokshana, Nusantara, Anggrek C., Nie, Linyan, Wu, Kaiqi, Elias Llumbet, Arturo, Woudstra, Willem, Mzyk, Aldona, Schirhagl, Romana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706807/
https://www.ncbi.nlm.nih.gov/pubmed/36354956
http://dx.doi.org/10.1021/acssensors.2c01272

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