Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines

BACKGROUND: COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigen...

Descripción completa

Detalles Bibliográficos
Autores principales: Godoy-Tena, Gerard, Barmada, Anis, Morante-Palacios, Octavio, de la Calle-Fabregat, Carlos, Martins-Ferreira, Ricardo, Ferreté-Bonastre, Anna G., Ciudad, Laura, Ruiz-Sanmartín, Adolfo, Martínez-Gallo, Mónica, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Rodríguez-Ubreva, Javier, Vento-Tormo, Roser, Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706884/
https://www.ncbi.nlm.nih.gov/pubmed/36443794
http://dx.doi.org/10.1186/s13073-022-01137-4

Ejemplares similares

Ejemplares similares