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Dual-energy CT assessment of rapid monosodium urate depletion and bone erosion remodelling during pegloticase plus methotrexate co-therapy

OBJECTIVES: Pegloticase rapidly lowers serum urate in uncontrolled/refractory gout patients, with ≥1 tophus resolution in 70% of pegloticase responders and 28% of non-responders. Dual-energy computed tomography (DECT) non-invasively detects MSU deposition, including subclinical deposition, quantifie...

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Detalles Bibliográficos
Autores principales: Dalbeth, Nicola, Becce, Fabio, Botson, John K, Zhao, Lin, Kumar, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707016/
https://www.ncbi.nlm.nih.gov/pubmed/35293984
http://dx.doi.org/10.1093/rheumatology/keac173