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Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells
Mitochondria are small organelles that play an essential role in the energy production of eukaryotic cells. Defects in their genomes are associated with diseases, such as aging and cancer. Here, we analyzed the mitochondrial genomes of 532 whole-genome sequencing samples from cancers and normal clon...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707047/ https://www.ncbi.nlm.nih.gov/pubmed/36458259 http://dx.doi.org/10.1016/j.isci.2022.105610 |