ODP282 Liver Dysfunction Monitoring in Patients With Turner Syndrome Followed at The Endocrinology Unit of a Tertiary Hospital in The Federal District (Brazil)

INTRODUCTION: Liver involvement is common in patients with Turner syndrome. Most patients are asymptomatic and the pathogenesis of these findings remains unclear. OBJECTIVES: The aim of this study is to correlate the main clinical, anthropometric and laboratory characteristics with the findings of hepatic elastography in patients with Turner syndrome. METHODS: We performed an observational cross-sectional study of adult patients diagnosed with Turner syndrome, confirmed by karyotype, without signs/symptoms of acute or chronic liver disease. Anthropometric and laboratory tests were done, including liver enzymes, lipid, and glycemic profile. Patients underwent liver health assessment using transient liver elastography at a tertiary hospital. Continuous variables were compared by Student's t-test and Mann-Whitney test as appropriate, while categorical variables were compared by Chi-square and Fisher exact test as appropriate. RESULTS: Twenty-three patients were enrolled and completed the study, with valid results from parameters of hepatic elastography. Patients who presented hepatic fibrosis risk on elastography, showed a higher concentration of triglycerides (p=0,046) and ALT/TGP (p=0. 028). The group with fatty liver showed higher concentrations of triglycerides (p=0. 033) and GGT (p=0. 046). Nine patients (34,8%) demonstrated intermediate risk of fibrosis and only one patient (4,8%) had a value suggestive of advanced fibrosis on liver elastography by kPa measurement. On the other hand, the CAP (Controlled Attenuation Parameter) identified steatosis grade I (S1) in 1/23 patients (4.3%), grade II (S2) in 1/23 patients (4.3%), and grade III (S3) in 7/23 patients (30.4%). Hepatic fibrosis and steatosis were not associated with the use of rhGH in childhood (p=0.190), neither with karyotype (p=0.675). CONCLUSIONS: Our data showed a mild relationship among findings of elastography and comorbidities/kariotype. We demonstrate the importance of elastography as a non-invasive method for assessing liver involvement in Turner's syndrome, identifying degrees of fibrosis and steatosis in this population. Thus, fibroscan, with the measures of LSM (liver stiffness measurement) and CAP, emerges as a promising technique in the routine assessment of liver health in patients with Turner syndrome. Presentation: No date and time listed