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Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma

BACKGROUND: Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits carcinogenic effects. However, the key mechanism of UCK2 promoting HCC and the...

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Detalles Bibliográficos
Autores principales:	Wu, Dehai, Zhang, Congyi, Liao, Guanqun, Leng, Kaiming, Dong, Bowen, Yu, Yang, Tai, Huilin, Huang, Lining, Luo, Feng, Zhang, Bin, Zhan, Tiexiang, Hu, Qiuhui, Tai, Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707060/ https://www.ncbi.nlm.nih.gov/pubmed/36447138 http://dx.doi.org/10.1186/s11658-022-00403-y

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