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Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience

BACKGROUND: The severe acute respiratory syndrome-related coronavirus 2 pandemic continues to this day worldwide. Individuals with COPD are at increased risk of contracting SARS-CoV-2. Most of the conducted studies are based on the clinical assessment of COVID-19 infection with different comorbiditi...

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Autores principales: Filippenko, Yevgeniya, Zagurovskaya, Marianna, Abdrakhmanova, Aigul, Kassenova, Saule, Zhakenova, Zhanar, Aimakhanova, Aizat, Zholdybay, Zhamilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707087/
http://dx.doi.org/10.1186/s43055-022-00932-8
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author Filippenko, Yevgeniya
Zagurovskaya, Marianna
Abdrakhmanova, Aigul
Kassenova, Saule
Zhakenova, Zhanar
Aimakhanova, Aizat
Zholdybay, Zhamilya
author_facet Filippenko, Yevgeniya
Zagurovskaya, Marianna
Abdrakhmanova, Aigul
Kassenova, Saule
Zhakenova, Zhanar
Aimakhanova, Aizat
Zholdybay, Zhamilya
author_sort Filippenko, Yevgeniya
collection PubMed
description BACKGROUND: The severe acute respiratory syndrome-related coronavirus 2 pandemic continues to this day worldwide. Individuals with COPD are at increased risk of contracting SARS-CoV-2. Most of the conducted studies are based on the clinical assessment of COVID-19 infection with different comorbidities. The specific contribution of COPD to the severity of the disease and outcome still remains the point of investigation. The main goals of our study are to assess COPD’s influence on the severity of clinical and CT characteristics of COVID-19 pneumonia and associated in-hospital mortality. RESULTS: This is a retrospective study on 281 patients with RT-PCR-confirmed COVID-19 infection and CT spectrum of COVID-19 pneumonia. Fifty patients have COPD based on CT criteria. No significant difference was observed in the mean hospital length of stay, arterial oxygen saturation on admission or in-hospital mortality between COPD and non-COPD groups. Patients with COPD were two times less likely to have fever less than 37.9 °C (RR = 2.037; 95% CI 1.114–3.724, p = 0.016), but higher absolute neutrophil count (p = 0.033) and median level of neutrophil/lymphocyte ratio (p = 0.029). The COPD group was presented with milder CT severity score (especially CT1, less than 25% of lung involvement) (p = 0.022), less likely to have bilateral (RR = 2.601; 95% CI: 1.341–5.044, p = 0.023) or central (RR = 1.754; 95% CI 1.024–3.003, p = 0.046) distribution of ground-glass opacities, right lower lobe (RR = 2.887; 95% CI 1.574–5.293, p = 0.008) or left lung (RR = 2.627; 95% CI 1.448–4.765, p = 0.009) involvement, and “crazy-paving” pattern (RR = 2.208; 95% CI 1.292–3.774, p = 0.003). Both moderate positive and negative relationship was observed between CT1, CT4, hypoxia and in-hospital mortality in the COPD group (r = − 0.383, p = 0.033; r = 0.486, p = 0.007; r = − 0,354, p = 0,022, respectively). CONCLUSION: The presence of COPD by imaging criteria in the settings of COVID-19-associated pneumonia did not significantly influence the clinical or imaging performance of the patients, nor was it linked to the increased in-hospital mortality.
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spelling pubmed-97070872022-11-29 Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience Filippenko, Yevgeniya Zagurovskaya, Marianna Abdrakhmanova, Aigul Kassenova, Saule Zhakenova, Zhanar Aimakhanova, Aizat Zholdybay, Zhamilya Egypt J Radiol Nucl Med Research BACKGROUND: The severe acute respiratory syndrome-related coronavirus 2 pandemic continues to this day worldwide. Individuals with COPD are at increased risk of contracting SARS-CoV-2. Most of the conducted studies are based on the clinical assessment of COVID-19 infection with different comorbidities. The specific contribution of COPD to the severity of the disease and outcome still remains the point of investigation. The main goals of our study are to assess COPD’s influence on the severity of clinical and CT characteristics of COVID-19 pneumonia and associated in-hospital mortality. RESULTS: This is a retrospective study on 281 patients with RT-PCR-confirmed COVID-19 infection and CT spectrum of COVID-19 pneumonia. Fifty patients have COPD based on CT criteria. No significant difference was observed in the mean hospital length of stay, arterial oxygen saturation on admission or in-hospital mortality between COPD and non-COPD groups. Patients with COPD were two times less likely to have fever less than 37.9 °C (RR = 2.037; 95% CI 1.114–3.724, p = 0.016), but higher absolute neutrophil count (p = 0.033) and median level of neutrophil/lymphocyte ratio (p = 0.029). The COPD group was presented with milder CT severity score (especially CT1, less than 25% of lung involvement) (p = 0.022), less likely to have bilateral (RR = 2.601; 95% CI: 1.341–5.044, p = 0.023) or central (RR = 1.754; 95% CI 1.024–3.003, p = 0.046) distribution of ground-glass opacities, right lower lobe (RR = 2.887; 95% CI 1.574–5.293, p = 0.008) or left lung (RR = 2.627; 95% CI 1.448–4.765, p = 0.009) involvement, and “crazy-paving” pattern (RR = 2.208; 95% CI 1.292–3.774, p = 0.003). Both moderate positive and negative relationship was observed between CT1, CT4, hypoxia and in-hospital mortality in the COPD group (r = − 0.383, p = 0.033; r = 0.486, p = 0.007; r = − 0,354, p = 0,022, respectively). CONCLUSION: The presence of COPD by imaging criteria in the settings of COVID-19-associated pneumonia did not significantly influence the clinical or imaging performance of the patients, nor was it linked to the increased in-hospital mortality. Springer Berlin Heidelberg 2022-11-29 2022 /pmc/articles/PMC9707087/ http://dx.doi.org/10.1186/s43055-022-00932-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Filippenko, Yevgeniya
Zagurovskaya, Marianna
Abdrakhmanova, Aigul
Kassenova, Saule
Zhakenova, Zhanar
Aimakhanova, Aizat
Zholdybay, Zhamilya
Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title_full Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title_fullStr Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title_full_unstemmed Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title_short Impact of COPD on clinical and CT characteristics of COVID-19-associated pneumonia: single tertiary center experience
title_sort impact of copd on clinical and ct characteristics of covid-19-associated pneumonia: single tertiary center experience
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707087/
http://dx.doi.org/10.1186/s43055-022-00932-8
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