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Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT)....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707499/ https://www.ncbi.nlm.nih.gov/pubmed/36384820 http://dx.doi.org/10.1192/bjo.2022.605 |
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author | Riblet, Natalie B. Shiner, Brian Young-Xu, Yinong Watts, Bradley V. |
author_facet | Riblet, Natalie B. Shiner, Brian Young-Xu, Yinong Watts, Bradley V. |
author_sort | Riblet, Natalie B. |
collection | PubMed |
description | Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT). Adding a single large study to existing meta-analyses may provide insights into lithium's anti-suicidal effects. We performed a meta-analysis of RCTs comparing lithium with a control condition for suicide prevention. MEDLINE and other databases were searched up to 30 November 2021. Efficacy was assessed by calculating the summary Peto odds ratio (OR) and incidence rate ratio (IRR) with 95% confidence intervals. Among seven RCTs, the odds of suicide were lower among patients receiving lithium versus control (OR = 0.30, 95% CI 0.09–1.02; IRR = 0.22, 95% CI 0.05–1.05), although the findings were still not statistically significant. The role of lithium in suicide prevention remains uncertain. |
format | Online Article Text |
id | pubmed-9707499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97074992022-12-05 Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials Riblet, Natalie B. Shiner, Brian Young-Xu, Yinong Watts, Bradley V. BJPsych Open Short Report Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT). Adding a single large study to existing meta-analyses may provide insights into lithium's anti-suicidal effects. We performed a meta-analysis of RCTs comparing lithium with a control condition for suicide prevention. MEDLINE and other databases were searched up to 30 November 2021. Efficacy was assessed by calculating the summary Peto odds ratio (OR) and incidence rate ratio (IRR) with 95% confidence intervals. Among seven RCTs, the odds of suicide were lower among patients receiving lithium versus control (OR = 0.30, 95% CI 0.09–1.02; IRR = 0.22, 95% CI 0.05–1.05), although the findings were still not statistically significant. The role of lithium in suicide prevention remains uncertain. Cambridge University Press 2022-11-17 /pmc/articles/PMC9707499/ /pubmed/36384820 http://dx.doi.org/10.1192/bjo.2022.605 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Short Report Riblet, Natalie B. Shiner, Brian Young-Xu, Yinong Watts, Bradley V. Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title | Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title_full | Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title_fullStr | Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title_full_unstemmed | Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title_short | Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
title_sort | lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707499/ https://www.ncbi.nlm.nih.gov/pubmed/36384820 http://dx.doi.org/10.1192/bjo.2022.605 |
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