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Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials

Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT)....

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Detalles Bibliográficos
Autores principales: Riblet, Natalie B., Shiner, Brian, Young-Xu, Yinong, Watts, Bradley V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707499/
https://www.ncbi.nlm.nih.gov/pubmed/36384820
http://dx.doi.org/10.1192/bjo.2022.605
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author Riblet, Natalie B.
Shiner, Brian
Young-Xu, Yinong
Watts, Bradley V.
author_facet Riblet, Natalie B.
Shiner, Brian
Young-Xu, Yinong
Watts, Bradley V.
author_sort Riblet, Natalie B.
collection PubMed
description Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT). Adding a single large study to existing meta-analyses may provide insights into lithium's anti-suicidal effects. We performed a meta-analysis of RCTs comparing lithium with a control condition for suicide prevention. MEDLINE and other databases were searched up to 30 November 2021. Efficacy was assessed by calculating the summary Peto odds ratio (OR) and incidence rate ratio (IRR) with 95% confidence intervals. Among seven RCTs, the odds of suicide were lower among patients receiving lithium versus control (OR = 0.30, 95% CI 0.09–1.02; IRR = 0.22, 95% CI 0.05–1.05), although the findings were still not statistically significant. The role of lithium in suicide prevention remains uncertain.
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spelling pubmed-97074992022-12-05 Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials Riblet, Natalie B. Shiner, Brian Young-Xu, Yinong Watts, Bradley V. BJPsych Open Short Report Controversy exists regarding the efficacy of lithium for suicide prevention. Except for a recent trial that enrolled over 500 patients, available trials of lithium for suicide prevention have involved small samples. It is challenging to measure suicide in a single randomised controlled trial (RCT). Adding a single large study to existing meta-analyses may provide insights into lithium's anti-suicidal effects. We performed a meta-analysis of RCTs comparing lithium with a control condition for suicide prevention. MEDLINE and other databases were searched up to 30 November 2021. Efficacy was assessed by calculating the summary Peto odds ratio (OR) and incidence rate ratio (IRR) with 95% confidence intervals. Among seven RCTs, the odds of suicide were lower among patients receiving lithium versus control (OR = 0.30, 95% CI 0.09–1.02; IRR = 0.22, 95% CI 0.05–1.05), although the findings were still not statistically significant. The role of lithium in suicide prevention remains uncertain. Cambridge University Press 2022-11-17 /pmc/articles/PMC9707499/ /pubmed/36384820 http://dx.doi.org/10.1192/bjo.2022.605 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Short Report
Riblet, Natalie B.
Shiner, Brian
Young-Xu, Yinong
Watts, Bradley V.
Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title_full Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title_fullStr Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title_full_unstemmed Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title_short Lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
title_sort lithium in the prevention of suicide in adults: systematic review and meta-analysis of clinical trials
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707499/
https://www.ncbi.nlm.nih.gov/pubmed/36384820
http://dx.doi.org/10.1192/bjo.2022.605
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