Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization

BACKGROUND: Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism of TCE and PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization of...

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Detalles Bibliográficos
Autores principales: Valdiviezo, Alan, Brown, Grace E., Michell, Ashlin R., Trinconi, Cristiana M., Bodke, Vedant V., Khetani, Salman R., Luo, Yu-Syuan, Chiu, Weihsueh A., Rusyn, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707501/
https://www.ncbi.nlm.nih.gov/pubmed/36445294
http://dx.doi.org/10.1289/EHP12006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707501/
https://www.ncbi.nlm.nih.gov/pubmed/36445294
http://dx.doi.org/10.1289/EHP12006

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