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Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization
BACKGROUND: Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism of TCE and PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization of...
Autores principales: | Valdiviezo, Alan, Brown, Grace E., Michell, Ashlin R., Trinconi, Cristiana M., Bodke, Vedant V., Khetani, Salman R., Luo, Yu-Syuan, Chiu, Weihsueh A., Rusyn, Ivan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Environmental Health Perspectives
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707501/ https://www.ncbi.nlm.nih.gov/pubmed/36445294 http://dx.doi.org/10.1289/EHP12006 |
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