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Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France

We enrolled 136 patients with laboratory-confirmed monkeypox during June 4–August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31–42 years). Of 136 patients, 125 (92%) were men who have sex with m...

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Autores principales: Cassir, Nadim, Cardona, Florian, Tissot-Dupont, Hervé, Bruel, Christiane, Doudier, Barbara, Lahouel, Salima, Bendamardji, Karim, Boschi, Céline, Aherfi, Sarah, Edouard, Sophie, Lagier, Jean-Christophe, Colson, Philippe, Gautret, Philippe, Fournier, Pierre-Edouard, Parola, Philippe, Brouqui, Philippe, La-Scola, Bernard, Million, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707593/
https://www.ncbi.nlm.nih.gov/pubmed/36241422
http://dx.doi.org/10.3201/eid2812.221440
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author Cassir, Nadim
Cardona, Florian
Tissot-Dupont, Hervé
Bruel, Christiane
Doudier, Barbara
Lahouel, Salima
Bendamardji, Karim
Boschi, Céline
Aherfi, Sarah
Edouard, Sophie
Lagier, Jean-Christophe
Colson, Philippe
Gautret, Philippe
Fournier, Pierre-Edouard
Parola, Philippe
Brouqui, Philippe
La-Scola, Bernard
Million, Matthieu
author_facet Cassir, Nadim
Cardona, Florian
Tissot-Dupont, Hervé
Bruel, Christiane
Doudier, Barbara
Lahouel, Salima
Bendamardji, Karim
Boschi, Céline
Aherfi, Sarah
Edouard, Sophie
Lagier, Jean-Christophe
Colson, Philippe
Gautret, Philippe
Fournier, Pierre-Edouard
Parola, Philippe
Brouqui, Philippe
La-Scola, Bernard
Million, Matthieu
author_sort Cassir, Nadim
collection PubMed
description We enrolled 136 patients with laboratory-confirmed monkeypox during June 4–August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31–42 years). Of 136 patients, 125 (92%) were men who have sex with men, 15 (11%) reported previous smallpox vaccinations, and 21 (15.5%) were HIV-positive. The most frequent lesion locations were the genitals (68 patients, 53%), perianal region (65 patients, 49%), and oral/perioral area (22 patients, 17%). Lesion locations largely corresponded with the route of contamination. Most (68%) patients had isolated anal, genital, or oral lesions when they were first seen, including 56 (61%) who had >1 positive site without a visible lesion. Concurrent sexually transmitted infections were diagnosed in 19 (15%) patients, and 7 patients (5%) were asymptomatic. We recommend vaccination campaigns, intensified testing for sexually transmitted infections, and increased contact tracing to control the ongoing monkeypox outbreak.
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spelling pubmed-97075932022-12-09 Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France Cassir, Nadim Cardona, Florian Tissot-Dupont, Hervé Bruel, Christiane Doudier, Barbara Lahouel, Salima Bendamardji, Karim Boschi, Céline Aherfi, Sarah Edouard, Sophie Lagier, Jean-Christophe Colson, Philippe Gautret, Philippe Fournier, Pierre-Edouard Parola, Philippe Brouqui, Philippe La-Scola, Bernard Million, Matthieu Emerg Infect Dis Research We enrolled 136 patients with laboratory-confirmed monkeypox during June 4–August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31–42 years). Of 136 patients, 125 (92%) were men who have sex with men, 15 (11%) reported previous smallpox vaccinations, and 21 (15.5%) were HIV-positive. The most frequent lesion locations were the genitals (68 patients, 53%), perianal region (65 patients, 49%), and oral/perioral area (22 patients, 17%). Lesion locations largely corresponded with the route of contamination. Most (68%) patients had isolated anal, genital, or oral lesions when they were first seen, including 56 (61%) who had >1 positive site without a visible lesion. Concurrent sexually transmitted infections were diagnosed in 19 (15%) patients, and 7 patients (5%) were asymptomatic. We recommend vaccination campaigns, intensified testing for sexually transmitted infections, and increased contact tracing to control the ongoing monkeypox outbreak. Centers for Disease Control and Prevention 2022-12 /pmc/articles/PMC9707593/ /pubmed/36241422 http://dx.doi.org/10.3201/eid2812.221440 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Cassir, Nadim
Cardona, Florian
Tissot-Dupont, Hervé
Bruel, Christiane
Doudier, Barbara
Lahouel, Salima
Bendamardji, Karim
Boschi, Céline
Aherfi, Sarah
Edouard, Sophie
Lagier, Jean-Christophe
Colson, Philippe
Gautret, Philippe
Fournier, Pierre-Edouard
Parola, Philippe
Brouqui, Philippe
La-Scola, Bernard
Million, Matthieu
Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title_full Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title_fullStr Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title_full_unstemmed Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title_short Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France
title_sort observational cohort study of evolving epidemiologic, clinical, and virologic features of monkeypox in southern france
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707593/
https://www.ncbi.nlm.nih.gov/pubmed/36241422
http://dx.doi.org/10.3201/eid2812.221440
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