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Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast, colon, and lung cancer. The use of TK inhibitors (gefitinib, erlotinib, lapatinib, and afatinib) and monoclonal anti...

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Detalles Bibliográficos
Autores principales:	Opo, F A Dain Md, Moulay, Mohammed, Zari, Ali, Alqaderi, Afnan, Alkarim, Saleh, Zari, Talal, Bhuiyan, Mohiuddin Ahmed, Mahmoud, Maged Mostafa, Aljoud, Fadwa, Suhail, Mohd, Edris, Sherif, Ramadan, Wafaa S., Kamal, Mohammad Amjad, Nemmiche, Saïd, Ahammad, Foysal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707641/ https://www.ncbi.nlm.nih.gov/pubmed/36457709 http://dx.doi.org/10.3389/fphar.2022.1027890

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