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A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control

Depression is associated with hyperactivity of the hypothalamo pituitary adrenal axis. Cortisol is a steroid hormone, released from the adrenal gland and is considered to be a biological marker of stress and anxiety. Serum or plasma cortisol levels have been previously studied in depressive patients...

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Autores principales: Sahu, Manoj K., Dubey, Rajesh K., Chandrakar, Alka, Kumar, Mahesh, Kumar, Mahendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707655/
https://www.ncbi.nlm.nih.gov/pubmed/36458076
http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_561_21
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author Sahu, Manoj K.
Dubey, Rajesh K.
Chandrakar, Alka
Kumar, Mahesh
Kumar, Mahendra
author_facet Sahu, Manoj K.
Dubey, Rajesh K.
Chandrakar, Alka
Kumar, Mahesh
Kumar, Mahendra
author_sort Sahu, Manoj K.
collection PubMed
description Depression is associated with hyperactivity of the hypothalamo pituitary adrenal axis. Cortisol is a steroid hormone, released from the adrenal gland and is considered to be a biological marker of stress and anxiety. Serum or plasma cortisol levels have been previously studied in depressive patients but reported contradictory results. The present meta analysis aims to assess the serum or plasma concentration of cortisol in depressive patients compared with controls. We have conducted a systematic review with sequential meta analysis according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, and PsycINFO databases, and published reference lists were searched up to January 2021. We have conducted a systematic review on PubMed for the following search (MeSH) terms (“Hydrocortisone”[Mesh]) AND “Depressive Disorder”[Mesh]). The RevMan 5.3 and Open Meta Analyst software was used with the standard mean difference (SMD) and 95% confidence intervals (CIs). The Jamovi and Open Meta Analyst Software were used to evaluate the publication bias, sensitivity analysis, and meta regression as possible sources of heterogeneity. Seventeen studies having a combined population (n) of 1400 (743 depressive patients and 657 controls) had satisfied the inclusion criteria for serum or plasma cortisol. The pooled SMD of the serum or plasma cortisol levels in depressive patients compared with controls was 1.18, (95% CI: 0.84, 1.52; P < 0.00001) with I2 = 85% (Ph < 0.00001). This meta analysis indicates a statistically significant mean difference in serum or plasma cortisol between depressed patients and controls. Meta analysis concluded that serum or plasma cortisol can differentiate depressed patients from nondepressed controls.
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spelling pubmed-97076552022-11-30 A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control Sahu, Manoj K. Dubey, Rajesh K. Chandrakar, Alka Kumar, Mahesh Kumar, Mahendra Indian J Psychiatry Review Article Depression is associated with hyperactivity of the hypothalamo pituitary adrenal axis. Cortisol is a steroid hormone, released from the adrenal gland and is considered to be a biological marker of stress and anxiety. Serum or plasma cortisol levels have been previously studied in depressive patients but reported contradictory results. The present meta analysis aims to assess the serum or plasma concentration of cortisol in depressive patients compared with controls. We have conducted a systematic review with sequential meta analysis according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, and PsycINFO databases, and published reference lists were searched up to January 2021. We have conducted a systematic review on PubMed for the following search (MeSH) terms (“Hydrocortisone”[Mesh]) AND “Depressive Disorder”[Mesh]). The RevMan 5.3 and Open Meta Analyst software was used with the standard mean difference (SMD) and 95% confidence intervals (CIs). The Jamovi and Open Meta Analyst Software were used to evaluate the publication bias, sensitivity analysis, and meta regression as possible sources of heterogeneity. Seventeen studies having a combined population (n) of 1400 (743 depressive patients and 657 controls) had satisfied the inclusion criteria for serum or plasma cortisol. The pooled SMD of the serum or plasma cortisol levels in depressive patients compared with controls was 1.18, (95% CI: 0.84, 1.52; P < 0.00001) with I2 = 85% (Ph < 0.00001). This meta analysis indicates a statistically significant mean difference in serum or plasma cortisol between depressed patients and controls. Meta analysis concluded that serum or plasma cortisol can differentiate depressed patients from nondepressed controls. Wolters Kluwer - Medknow 2022 2022-10-12 /pmc/articles/PMC9707655/ /pubmed/36458076 http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_561_21 Text en Copyright: © 2022 Indian Journal of Psychiatry https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Sahu, Manoj K.
Dubey, Rajesh K.
Chandrakar, Alka
Kumar, Mahesh
Kumar, Mahendra
A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title_full A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title_fullStr A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title_full_unstemmed A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title_short A systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
title_sort systematic review and meta-analysis of serum and plasma cortisol levels in depressed patients versus control
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707655/
https://www.ncbi.nlm.nih.gov/pubmed/36458076
http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_561_21
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