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Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia

As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their populatio...

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Autores principales: Askapuli, Ayken, Vilar, Miguel, Garcia-Ortiz, Humberto, Zhabagin, Maxat, Sabitov, Zhaxylyk, Akilzhanova, Ainur, Ramanculov, Erlan, Schamiloglu, Uli, Martinez-Hernandez, Angelica, Contreras-Cubas, Cecilia, Barajas-Olmos, Francisco, Schurr, Theodore G., Zhumadilov, Zhaxybay, Flores-Huacuja, Marlen, Orozco, Lorena, Hawks, John, Saitou, Naruya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707748/
https://www.ncbi.nlm.nih.gov/pubmed/36445929
http://dx.doi.org/10.1371/journal.pone.0277771
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author Askapuli, Ayken
Vilar, Miguel
Garcia-Ortiz, Humberto
Zhabagin, Maxat
Sabitov, Zhaxylyk
Akilzhanova, Ainur
Ramanculov, Erlan
Schamiloglu, Uli
Martinez-Hernandez, Angelica
Contreras-Cubas, Cecilia
Barajas-Olmos, Francisco
Schurr, Theodore G.
Zhumadilov, Zhaxybay
Flores-Huacuja, Marlen
Orozco, Lorena
Hawks, John
Saitou, Naruya
author_facet Askapuli, Ayken
Vilar, Miguel
Garcia-Ortiz, Humberto
Zhabagin, Maxat
Sabitov, Zhaxylyk
Akilzhanova, Ainur
Ramanculov, Erlan
Schamiloglu, Uli
Martinez-Hernandez, Angelica
Contreras-Cubas, Cecilia
Barajas-Olmos, Francisco
Schurr, Theodore G.
Zhumadilov, Zhaxybay
Flores-Huacuja, Marlen
Orozco, Lorena
Hawks, John
Saitou, Naruya
author_sort Askapuli, Ayken
collection PubMed
description As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex history for this population. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. Our analyses further indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers.
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spelling pubmed-97077482022-11-30 Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia Askapuli, Ayken Vilar, Miguel Garcia-Ortiz, Humberto Zhabagin, Maxat Sabitov, Zhaxylyk Akilzhanova, Ainur Ramanculov, Erlan Schamiloglu, Uli Martinez-Hernandez, Angelica Contreras-Cubas, Cecilia Barajas-Olmos, Francisco Schurr, Theodore G. Zhumadilov, Zhaxybay Flores-Huacuja, Marlen Orozco, Lorena Hawks, John Saitou, Naruya PLoS One Research Article As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex history for this population. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. Our analyses further indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers. Public Library of Science 2022-11-29 /pmc/articles/PMC9707748/ /pubmed/36445929 http://dx.doi.org/10.1371/journal.pone.0277771 Text en © 2022 Askapuli et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Askapuli, Ayken
Vilar, Miguel
Garcia-Ortiz, Humberto
Zhabagin, Maxat
Sabitov, Zhaxylyk
Akilzhanova, Ainur
Ramanculov, Erlan
Schamiloglu, Uli
Martinez-Hernandez, Angelica
Contreras-Cubas, Cecilia
Barajas-Olmos, Francisco
Schurr, Theodore G.
Zhumadilov, Zhaxybay
Flores-Huacuja, Marlen
Orozco, Lorena
Hawks, John
Saitou, Naruya
Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title_full Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title_fullStr Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title_full_unstemmed Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title_short Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia
title_sort kazak mitochondrial genomes provide insights into the human population history of central eurasia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707748/
https://www.ncbi.nlm.nih.gov/pubmed/36445929
http://dx.doi.org/10.1371/journal.pone.0277771
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