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Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device

AIMS: We sought to evaluate the reliability and diagnostic accuracy of a novel handheld ultrasound device (HUD) with artificial intelligence (AI) assisted algorithm to automatically calculate ejection fraction (autoEF) in a real-world patient population. METHODS AND RESULTS: We studied 100 consecuti...

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Autores principales: Papadopoulou, Stella-Lida, Sachpekidis, Vasileios, Kantartzi, Vasiliki, Styliadis, Ioannis, Nihoyannopoulos, Petros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707920/
https://www.ncbi.nlm.nih.gov/pubmed/36713988
http://dx.doi.org/10.1093/ehjdh/ztac001
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author Papadopoulou, Stella-Lida
Sachpekidis, Vasileios
Kantartzi, Vasiliki
Styliadis, Ioannis
Nihoyannopoulos, Petros
author_facet Papadopoulou, Stella-Lida
Sachpekidis, Vasileios
Kantartzi, Vasiliki
Styliadis, Ioannis
Nihoyannopoulos, Petros
author_sort Papadopoulou, Stella-Lida
collection PubMed
description AIMS: We sought to evaluate the reliability and diagnostic accuracy of a novel handheld ultrasound device (HUD) with artificial intelligence (AI) assisted algorithm to automatically calculate ejection fraction (autoEF) in a real-world patient population. METHODS AND RESULTS: We studied 100 consecutive patients (57 ± 15 years old, 61% male), including 38 with abnormal left ventricular (LV) function [LV ejection fraction (LVEF) < 50%]. The autoEF results acquired using the HUD were independently compared with manually traced biplane Simpson’s rule measurements on cart-based systems to assess method agreement using intra-class correlation coefficient (ICC), linear regression analysis, and Bland–Altman analysis. The diagnostic accuracy for the detection of LVEF <50% was also calculated. Test–retest reliability of measured EF by the HUD was assessed by calculating the ICC and the minimal detectable change (MDC). The ICC, linear regression analysis, and Bland–Altman analysis revealed good agreement between autoEF and reference manual EF (ICC = 0.85; r = 0.87, P < 0.001; mean bias −1.42% with limits of agreement 14.5%, respectively). Detection of abnormal LV function (EF < 50%) by autoEF algorithm was feasible with sensitivity 90% (95% CI 75–97%), specificity 87% (95% CI 76–94%), PPV 81% (95% CI 66–91%), NPV 93% (95% CI 83–98%), and a total diagnostic accuracy of 88%. Test–retest reliability was excellent (ICC = 0.91, P < 0.001; r = 0.91, P < 0.001; mean difference ± SD: 0.54% ± 5.27%, P = 0.308) and MDC for LVEF measurement by autoEF was calculated at 4.38%. CONCLUSION: Use of a novel HUD with AI-enabled capabilities provided similar LVEF results with those derived by manual biplane Simpson’s method on cart-based systems and shows clinical potential.
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spelling pubmed-97079202023-01-27 Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device Papadopoulou, Stella-Lida Sachpekidis, Vasileios Kantartzi, Vasiliki Styliadis, Ioannis Nihoyannopoulos, Petros Eur Heart J Digit Health Original Articles AIMS: We sought to evaluate the reliability and diagnostic accuracy of a novel handheld ultrasound device (HUD) with artificial intelligence (AI) assisted algorithm to automatically calculate ejection fraction (autoEF) in a real-world patient population. METHODS AND RESULTS: We studied 100 consecutive patients (57 ± 15 years old, 61% male), including 38 with abnormal left ventricular (LV) function [LV ejection fraction (LVEF) < 50%]. The autoEF results acquired using the HUD were independently compared with manually traced biplane Simpson’s rule measurements on cart-based systems to assess method agreement using intra-class correlation coefficient (ICC), linear regression analysis, and Bland–Altman analysis. The diagnostic accuracy for the detection of LVEF <50% was also calculated. Test–retest reliability of measured EF by the HUD was assessed by calculating the ICC and the minimal detectable change (MDC). The ICC, linear regression analysis, and Bland–Altman analysis revealed good agreement between autoEF and reference manual EF (ICC = 0.85; r = 0.87, P < 0.001; mean bias −1.42% with limits of agreement 14.5%, respectively). Detection of abnormal LV function (EF < 50%) by autoEF algorithm was feasible with sensitivity 90% (95% CI 75–97%), specificity 87% (95% CI 76–94%), PPV 81% (95% CI 66–91%), NPV 93% (95% CI 83–98%), and a total diagnostic accuracy of 88%. Test–retest reliability was excellent (ICC = 0.91, P < 0.001; r = 0.91, P < 0.001; mean difference ± SD: 0.54% ± 5.27%, P = 0.308) and MDC for LVEF measurement by autoEF was calculated at 4.38%. CONCLUSION: Use of a novel HUD with AI-enabled capabilities provided similar LVEF results with those derived by manual biplane Simpson’s method on cart-based systems and shows clinical potential. Oxford University Press 2022-01-20 /pmc/articles/PMC9707920/ /pubmed/36713988 http://dx.doi.org/10.1093/ehjdh/ztac001 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
Papadopoulou, Stella-Lida
Sachpekidis, Vasileios
Kantartzi, Vasiliki
Styliadis, Ioannis
Nihoyannopoulos, Petros
Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title_full Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title_fullStr Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title_full_unstemmed Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title_short Clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
title_sort clinical validation of an artificial intelligence-assisted algorithm for automated quantification of left ventricular ejection fraction in real time by a novel handheld ultrasound device
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707920/
https://www.ncbi.nlm.nih.gov/pubmed/36713988
http://dx.doi.org/10.1093/ehjdh/ztac001
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