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Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidogl...

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Autores principales: Meng, Yun, Chen, Lijie, Chen, Yang, Shi, Jieyun, Zhang, Zheng, Wang, Yiwen, Wu, Fan, Jiang, Xingwu, Yang, Wei, Zhang, Li, Wang, Chaochao, Meng, Xianfu, Wu, Yelin, Bu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708144/
https://www.ncbi.nlm.nih.gov/pubmed/36446788
http://dx.doi.org/10.1038/s41467-022-35050-6
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author Meng, Yun
Chen, Lijie
Chen, Yang
Shi, Jieyun
Zhang, Zheng
Wang, Yiwen
Wu, Fan
Jiang, Xingwu
Yang, Wei
Zhang, Li
Wang, Chaochao
Meng, Xianfu
Wu, Yelin
Bu, Wenbo
author_facet Meng, Yun
Chen, Lijie
Chen, Yang
Shi, Jieyun
Zhang, Zheng
Wang, Yiwen
Wu, Fan
Jiang, Xingwu
Yang, Wei
Zhang, Li
Wang, Chaochao
Meng, Xianfu
Wu, Yelin
Bu, Wenbo
author_sort Meng, Yun
collection PubMed
description Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.
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spelling pubmed-97081442022-11-30 Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing Meng, Yun Chen, Lijie Chen, Yang Shi, Jieyun Zhang, Zheng Wang, Yiwen Wu, Fan Jiang, Xingwu Yang, Wei Zhang, Li Wang, Chaochao Meng, Xianfu Wu, Yelin Bu, Wenbo Nat Commun Article Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation. Nature Publishing Group UK 2022-11-29 /pmc/articles/PMC9708144/ /pubmed/36446788 http://dx.doi.org/10.1038/s41467-022-35050-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Meng, Yun
Chen, Lijie
Chen, Yang
Shi, Jieyun
Zhang, Zheng
Wang, Yiwen
Wu, Fan
Jiang, Xingwu
Yang, Wei
Zhang, Li
Wang, Chaochao
Meng, Xianfu
Wu, Yelin
Bu, Wenbo
Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title_full Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title_fullStr Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title_full_unstemmed Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title_short Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
title_sort reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708144/
https://www.ncbi.nlm.nih.gov/pubmed/36446788
http://dx.doi.org/10.1038/s41467-022-35050-6
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