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rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality

The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and coronavirus disease 2019 (COVID-19) mortality...

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Autores principales: Beheshti Shirazi, Saeedeh Sadat, Sakhaee, Fatemeh, Sotoodehnejadnematalahi, Fattah, Zamani, Mohammad Saber, Ahmadi, Iraj, Anvari, Enayat, Fateh, Abolfazl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708353/
https://www.ncbi.nlm.nih.gov/pubmed/36457338
http://dx.doi.org/10.1155/2022/7841969
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author Beheshti Shirazi, Saeedeh Sadat
Sakhaee, Fatemeh
Sotoodehnejadnematalahi, Fattah
Zamani, Mohammad Saber
Ahmadi, Iraj
Anvari, Enayat
Fateh, Abolfazl
author_facet Beheshti Shirazi, Saeedeh Sadat
Sakhaee, Fatemeh
Sotoodehnejadnematalahi, Fattah
Zamani, Mohammad Saber
Ahmadi, Iraj
Anvari, Enayat
Fateh, Abolfazl
author_sort Beheshti Shirazi, Saeedeh Sadat
collection PubMed
description The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and coronavirus disease 2019 (COVID-19) mortality. TMPRSS2 rs12329760 polymorphism was genotyped using the tetraprimer amplification refractory mutation system-polymerase chain reaction method in 592 dead and 693 improved patients. In the current study, the frequency of TMPRSS2 rs12329760 CC than TT genotypes was significantly lower in improved patients than in dead patients. According to the findings of the multivariate logistic regression test, higher levels of mean age, creatinine, erythrocyte sedimentation rate, C-reactive protein, aspartate aminotransferase, lower levels of 25-hydroxyvitamin D, uric acid, and real-time PCR Ct values and TMPRSS2 rs12329760 CC genotype were observed to be associated with increased COVID-19 mortality rates. In conclusion, the TMPRSS2 rs12329760 CC genotype was a polymorphism linked to a significantly higher incidence of severe COVID-19. Further studies are required to corroborate the obtained findings.
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spelling pubmed-97083532022-11-30 rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality Beheshti Shirazi, Saeedeh Sadat Sakhaee, Fatemeh Sotoodehnejadnematalahi, Fattah Zamani, Mohammad Saber Ahmadi, Iraj Anvari, Enayat Fateh, Abolfazl Biomed Res Int Research Article The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and coronavirus disease 2019 (COVID-19) mortality. TMPRSS2 rs12329760 polymorphism was genotyped using the tetraprimer amplification refractory mutation system-polymerase chain reaction method in 592 dead and 693 improved patients. In the current study, the frequency of TMPRSS2 rs12329760 CC than TT genotypes was significantly lower in improved patients than in dead patients. According to the findings of the multivariate logistic regression test, higher levels of mean age, creatinine, erythrocyte sedimentation rate, C-reactive protein, aspartate aminotransferase, lower levels of 25-hydroxyvitamin D, uric acid, and real-time PCR Ct values and TMPRSS2 rs12329760 CC genotype were observed to be associated with increased COVID-19 mortality rates. In conclusion, the TMPRSS2 rs12329760 CC genotype was a polymorphism linked to a significantly higher incidence of severe COVID-19. Further studies are required to corroborate the obtained findings. Hindawi 2022-11-22 /pmc/articles/PMC9708353/ /pubmed/36457338 http://dx.doi.org/10.1155/2022/7841969 Text en Copyright © 2022 Saeedeh Sadat Beheshti Shirazi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Beheshti Shirazi, Saeedeh Sadat
Sakhaee, Fatemeh
Sotoodehnejadnematalahi, Fattah
Zamani, Mohammad Saber
Ahmadi, Iraj
Anvari, Enayat
Fateh, Abolfazl
rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title_full rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title_fullStr rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title_full_unstemmed rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title_short rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality
title_sort rs12329760 polymorphism in transmembrane serine protease 2 gene and risk of coronavirus disease 2019 mortality
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708353/
https://www.ncbi.nlm.nih.gov/pubmed/36457338
http://dx.doi.org/10.1155/2022/7841969
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