Cargando…

The effect of neoadjuvant therapy on PD-L1 expression and CD8+lymphocyte density in non-small cell lung cancer

PD-L1 expression is the routine clinical biomarker for the selection of patients to receive immunotherapy in non-small cell lung cancer (NSCLC). However, the application and best timing of immunotherapy in the resectable setting is still under investigation. We aimed to study the effect of chemother...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zens, Philipp, Bello, Corina, Scherz, Amina, von Gunten, Michael, Ochsenbein, Adrian, Schmid, Ralph A., Berezowska, Sabina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708547/ https://www.ncbi.nlm.nih.gov/pubmed/35915139 http://dx.doi.org/10.1038/s41379-022-01139-y

Ejemplares similares

A prognostic score for non-small cell lung cancer resected after neoadjuvant therapy in comparison with the tumor-node-metastases classification and major pathological response
por: Zens, Philipp, et al.
Publicado: (2021)

Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy
por: Losmanova, Tereza, et al.
Publicado: (2021)

Programmed Death-Ligand 1 Expression in Lung Cancer and Paired Brain Metastases—a Single-Center Study in 190 Patients
por: Kündig, Alexandra, et al.
Publicado: (2022)

Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma
por: Yang, Haitang, et al.
Publicado: (2022)

Comparison of the 7th and 8th Edition of the UICC/AJCC TNM Staging System in Primary Resected Squamous Cell Carcinomas of the Lung—A Single Center Analysis of 354 Cases
por: Neppl, Christina, et al.
Publicado: (2019)

Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients
por: Shen, Jian, et al.
Publicado: (2022)

MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
por: Yang, Haitang, et al.
Publicado: (2023)

Functional and molecular characterization of PD1(+) tumor-infiltrating lymphocytes from lung cancer patients
por: Lipp, Jesse J., et al.
Publicado: (2022)

Neoadjuvant/Perioperative Treatment Affects Spatial Distribution and Densities of Tumor Associated Neutrophils and CD8+ Lymphocytes in Gastric Cancer
por: Hoffmann, Anne, et al.
Publicado: (2021)

CD27 Expression Promotes Long-Term Survival of Functional Effector–Memory CD8(+)Cytotoxic T Lymphocytes in HIV-infected Patients
por: Ochsenbein, Adrian F., et al.
Publicado: (2004)

Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma
por: Wang, Jun, et al.
Publicado: (2023)

PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus
por: Fassan, Matteo, et al.
Publicado: (2019)

Density and distribution of lymphocytes in pretherapeutic rectal cancer and response to neoadjuvant therapy
por: Lai, Sicong, et al.
Publicado: (2020)

Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities
por: Haas, Quentin, et al.
Publicado: (2022)

Peripheral CD8+CD28+ T lymphocytes predict the efficacy and safety of PD-1/PD-L1 inhibitors in cancer patients
por: Geng, Ruixuan, et al.
Publicado: (2023)

Neoadjuvant treatment does not influence PD-L1 expression in stage III non-small-cell lung cancer: a retrospective analysis of tumor samples from the trials SAKK 16/96, 16/00, 16/01, and 16/14
por: König, D., et al.
Publicado: (2023)

Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
por: Gao, Yanyun, et al.
Publicado: (2021)

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127(+) and KLRG1(+) CD8 T cells
por: Hui, Zhenzhen, et al.
Publicado: (2023)

Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis
por: Däster, Silvio, et al.
Publicado: (2020)

Deciphering Microenvironment of NSCLC based on CD8+ TIL Density and PD-1/PD-L1 Expression
por: Lin, Ziying, et al.
Publicado: (2019)

Glial cells suppress postencephalitic CD8(+) T lymphocytes through PD‐L1
por: Schachtele, Scott J., et al.
Publicado: (2014)

Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS
por: Goovaerts, Odin, et al.
Publicado: (2019)

Tumor-infiltrating CD8+ and FOXP3+ lymphocytes before and after neoadjuvant chemotherapy in cervical cancer
por: Liang, Yun, et al.
Publicado: (2018)

The Predictive Value of CD3+/CD8+ Lymphocyte Infiltration and PD-L1 Expression in Colorectal Cancer
por: Liu, Jihong, et al.
Publicado: (2023)

Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1(+)CD8(+) and CD8(+) T cells as predictive of response to neoadjuvant chemotherapy in breast cancer
por: Liang, Hongling, et al.
Publicado: (2020)

Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer
por: Wang, Limei, et al.
Publicado: (2021)

Patterns of Carbon-Bound Exogenous Compounds Impact Disease Pathophysiology in Lung Cancer Subtypes in Different Ways
por: Shen, Jian, et al.
Publicado: (2023)

Modulating CD27 signaling to treat cancer
por: Riether, Carsten, et al.
Publicado: (2012)

Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas
por: Langer, Rupert, et al.
Publicado: (2018)

PD-1/PD-L1 expression is frequent and correlated with lymphocyte density in Erdheim-Chester disease
por: Charlotte, Fréderic, et al.
Publicado: (2022)

Association between Apoptotis and CD4(+)/CD8(+) T-Lymphocyte Ratio in Aseptic Loosening after Total Hip Replacement
por: Landgraeber, Stefan, et al.
Publicado: (2009)

PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer
por: Meng, Ying, et al.
Publicado: (2018)

Regulatory T-cell density and cytotoxic T lymphocyte density are associated with complete response to neoadjuvant paclitaxel and carboplatin chemoradiotherapy in gastric cancer
por: Huang, Di, et al.
Publicado: (2018)

Accumulation of CD5(+)CD19(+) B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsils
por: Wlasiuk, Paulina, et al.
Publicado: (2015)

EBV(+) and MSI Gastric Cancers Harbor High PD-L1/PD-1 Expression and High CD8(+) Intratumoral Lymphocytes
por: De Rosa, Simona, et al.
Publicado: (2018)

CD11c(+) and IRF8(+) cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy
por: Tse, Benita C. Y., et al.
Publicado: (2023)

Fibrosierte Hypersensitivitätspneumonie: Fokus auf pathologierelevante Aspekte der neuen klinischen Leitlinie der ATS/JRS/ALAT zur Diagnostik der Hypersensitivitätspneumonie bei Erwachsenen
por: Berezowska, Sabina
Publicado: (2020)

Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model
por: Bichsel, Colette A., et al.
Publicado: (2017)

Increased CD4/CD8 Lymphocyte ratio predicts favourable neoadjuvant treatment response in gastric cancer: A prospective pilot study
por: Skubleny, Daniel, et al.
Publicado: (2023)

Niche-specific MHC II and PD-L1 regulate CD4(+)CD8αα(+) intraepithelial lymphocyte differentiation
por: Moon, Sookjin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3vbnbabqeil61rcgrqlvkcns0n